IFIT1

This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

Interferon Induced Protein With Tetratricopeptide Repeats 1

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

Antiviral innate immune response Source: ARUK-UCL
Cellular response to exogenous dsRNA Source: BHF-UCL
Cellular response to type I interferon Source: BHF-UCL
Defense response to virus Source: GO_Central
Intracellular transport of viral protein in host cell Source: BHF-UCL
Negative regulation of helicase activity Source: BHF-UCL
Negative regulation of protein binding Source: BHF-UCL
Negative regulation of viral genome replication Source: UniProtKB
Positive regulation of viral genome replication Source: BHF-UCL
Regulation of defense response to virus Source: InterPro
Response to virus Source: BHF-UCL

Cytoplasm

Phosphorylated.
ISGylated.