Rabbit Anti-IL13RA2 Recombinant Antibody (EG1632) (CBMAB-EN1953-LY)

Name: Rabbit Anti-IL13RA2 Recombinant Antibody (EG1632)
SKU: CBMAB-EN1953-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1632

Application

WB: 1:500~1:1000 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human IL13RA2.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 13 Receptor Subunit Alpha 2

Introduction

The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]

Entrez Gene ID

3598

UniProt ID

Q14627

Alternative Names

Interleukin 13 Receptor Subunit Alpha 2

Function

Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

Biological Process

Cytokine-mediated signaling pathway Source: GO_Central
Immunoglobulin mediated immune response Source: Ensembl
Negative regulation of immunoglobulin production Source: Ensembl
Negative regulation of mast cell degranulation Source: Ensembl

Cellular Location

Membrane

Topology

Extracellular: 27-343
Helical: 344-363
Cytoplasmic: 364-380

Subham, S., Jeppson, J. D., Schatmeyer, B., Forman, S. J., Brown, C. E., & Akhavan, D. (2023). Protein kinase C is an upstream regulator of IL13Ra2 and small molecular activator enhances CAR T mediated killing. Cancer Research, 83(7_Supplement), 3235-3235.

Hotblack, A., Wawrzyniecka, P., Cheng, G. W. K., Nannini, F., Pule, M., & Straathof, K. (2022). IMMU-16. Next-generation CAR T-cells targeting IL13RA2 and secreting IL-15 achieve durable tumour clearance in pre-clinical model of diffuse midline glioma. Neuro-Oncology, 24(Suppl 1), i85.

Rossmeisl, J. H., Herpai, D., Quigley, M., Cecere, T. E., Robertson, J. L., D’Agostino, R. B., ... & Debinski, W. (2021). Phase I trial of convection-enhanced delivery of IL13RA2 and EPHA2 receptor targeted cytotoxins in dogs with spontaneous intracranial gliomas. Neuro-oncology, 23(3), 422-434.

Zeng, J., Zhang, J., Yang, Y. Z., Wang, F., Jiang, H., Chen, H. D., ... & Hu, W. M. (2020). IL13RA2 is overexpressed in malignant gliomas and related to clinical outcome of patients. American Journal of Translational Research, 12(8), 4702.

Wang, M., Yao, R., & Wang, Y. (2020). Silencing of IL13RA2 promotes partial epithelial‐mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation. FEBS Open bio, 10(2), 229-236.

Verstockt, B., Verstockt, S., Creyns, B., Tops, S., Van Assche, G., Gils, A., ... & Breynaert, C. (2019). Mucosal IL13RA2 expression predicts nonresponse to anti‐TNF therapy in Crohn's disease. Alimentary Pharmacology & Therapeutics, 49(5), 572-581.

Chong, S. T., Tan, K. M., Kok, C. Y., Guan, S. P., Lai, S. H., Lim, C., ... & Ngeow, J. (2019). IL13RA2 is differentially regulated in papillary thyroid carcinoma vs follicular thyroid carcinoma. The Journal of Clinical Endocrinology & Metabolism, 104(11), 5573-5584.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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