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Mouse Anti-IL19 (AA 0411-10) Recombinant Antibody (MM0383-1G54) (CBMAB-I0884-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
MM0383-1G54
Antibody Isotype
IgG1
Application
FC, BL, CyTOF, WB, Neut

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA0411-10

Target

Full Name
Interleukin 19
Introduction
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
Entrez Gene ID
29949
UniProt ID
Q9UHD0
Alternative Names
Interleukin 19
Function
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).
Biological Process
Apoptotic process Source: UniProtKB-KW
Immune response Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of low-density lipoprotein particle clearance Source: Ensembl
Positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Reactive oxygen species metabolic process Source: Ensembl
Signal transduction Source: UniProtKB
Cellular Location
Secreted
More Infomation

Della Bella, C., Antico, A., Panozzo, M. P., Capitani, N., Benagiano, M., Petrone, L., ... & D’Elios, M. M. (2022). Elevated IL-19 serum levels in patients with pernicious anemia and autoimmune gastritis. Frontiers in Immunology, 13, 887256.

Chen, W., Xing, J., Liu, X., Wang, S., & Xing, D. (2021). The role and transformative potential of IL-19 in atherosclerosis. Cytokine & Growth Factor Reviews, 62, 70-82.

Azuma, Y. T., Fujita, T., Izawa, T., Hirota, K., Nishiyama, K., Ikegami, A., ... & Tsuneyama, K. (2021). Il-19 contributes to the development of nonalcoholic steatohepatitis by altering lipid metabolism. Cells, 10(12), 3513.

Dogan, M., Sahin, M., & Yenisey, C. (2019). Increased TSLP, IL-33, IL-25, IL-19, IL 21 and amphiregulin (AREG) levels in chronic rhinosinusitis with nasal polyp. European Archives of Oto-Rhino-Laryngology, 276, 1685-1691.

An, W., Yu, Y., Zhang, Y., Zhang, Z., Yu, Y., & Zhao, X. (2019). Exogenous IL‐19 attenuates acute ischaemic injury and improves survival in male mice with myocardial infarction. British journal of pharmacology, 176(5), 699-710.

Weng, Y. H., Chen, W. Y., Lin, Y. L., Wang, J. Y., & Chang, M. S. (2019). Blocking IL-19 signaling ameliorates allergen-induced airway inflammation. Frontiers in Immunology, 10, 968.

Konrad, R. J., Higgs, R. E., Rodgers, G. H., Ming, W., Qian, Y. W., Bivi, N., ... & Nickoloff, B. J. (2019). Assessment and clinical relevance of serum IL-19 levels in psoriasis and atopic dermatitis using a sensitive and specific novel immunoassay. Scientific Reports, 9(1), 5211.

Ray, M., Gabunia, K., Vrakas, C. N., Herman, A. B., Kako, F., Kelemen, S. E., ... & Autieri, M. V. (2018). Genetic deletion of IL-19 (interleukin-19) exacerbates atherogenesis in Il19−/−× Ldlr−/− double knockout mice by dysregulation of mRNA stability protein HuR (human antigen R). Arteriosclerosis, thrombosis, and vascular biology, 38(6), 1297-1308.

Autieri, M. V. (2018). IL-19 and other IL-20 family member cytokines in vascular inflammatory diseases. Frontiers in Immunology, 9, 700.

Herman, A. B., Vrakas, C. N., Ray, M., Kelemen, S. E., Sweredoski, M. J., Moradian, A., ... & Autieri, M. V. (2018). FXR1 is an IL-19-responsive RNA-binding protein that destabilizes pro-inflammatory transcripts in vascular smooth muscle cells. Cell reports, 24(5), 1176-1189.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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