IL19
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 19
Function
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).
Biological Process
Apoptotic process Source: UniProtKB-KW
Immune response Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of low-density lipoprotein particle clearance Source: Ensembl
Positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Reactive oxygen species metabolic process Source: Ensembl
Signal transduction Source: UniProtKB
Immune response Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of low-density lipoprotein particle clearance Source: Ensembl
Positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Reactive oxygen species metabolic process Source: Ensembl
Signal transduction Source: UniProtKB
Cellular Location
Secreted
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Anti-IL19 antibodies
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Target: IL19
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A494
Application*: ICC, IHC, IP, WB
Target: IL19
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rabbit, Rat
Clone: A493
Application*: ICC, IHC, IP, WB
Target: IL19
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Pig, Rabbit, Rat
Clone: A492
Application*: ICC, IHC, IP, WB
Target: IL19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A491
Application*: ELISA, IHC, WB
Target: IL19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF226
Application*: ELISA, IHC, WB
Target: IL19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1345
Application*: E, IH, WB
Target: IL19
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: RN19
Application*: E, F
Target: IL19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0383-1G54
Application*: F, BL, MC, WB, N
Target: IL19
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 152112
Application*: N, IS, MC
Target: IL19
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0153
Application*: N
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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