IL19

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Interleukin 19

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

Apoptotic process Source: UniProtKB-KW
Immune response Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of low-density lipoprotein particle clearance Source: Ensembl
Positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Reactive oxygen species metabolic process Source: Ensembl
Signal transduction Source: UniProtKB

Secreted