Human Recombinant IL19 protein, His Tag (V2LY-0526-LY4801)

Name: Human Recombinant IL19 protein, His Tag
SKU: V2LY-0526-LY4801
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant IL19 protein, His Tag consist of Amino Acid: 1-177 and predicts a molecular mass of 19.2 kDa.

Molecule Mass

19.2 kDa

Sequence

Amino Acid: 1-177

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 19

Function

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

Biological Process

Apoptotic process Source: UniProtKB-KW
Immune response Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of low-density lipoprotein particle clearance Source: Ensembl
Positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Reactive oxygen species metabolic process Source: Ensembl
Signal transduction Source: UniProtKB

Cellular Location

Secreted

Della Bella, C., Antico, A., Panozzo, M. P., Capitani, N., Benagiano, M., Petrone, L., ... & D’Elios, M. M. (2022). Elevated IL-19 serum levels in patients with pernicious anemia and autoimmune gastritis. Frontiers in Immunology, 13, 887256.

Chen, W., Xing, J., Liu, X., Wang, S., & Xing, D. (2021). The role and transformative potential of IL-19 in atherosclerosis. Cytokine & Growth Factor Reviews, 62, 70-82.

Azuma, Y. T., Fujita, T., Izawa, T., Hirota, K., Nishiyama, K., Ikegami, A., ... & Tsuneyama, K. (2021). Il-19 contributes to the development of nonalcoholic steatohepatitis by altering lipid metabolism. Cells, 10(12), 3513.

Dogan, M., Sahin, M., & Yenisey, C. (2019). Increased TSLP, IL-33, IL-25, IL-19, IL 21 and amphiregulin (AREG) levels in chronic rhinosinusitis with nasal polyp. European Archives of Oto-Rhino-Laryngology, 276, 1685-1691.

An, W., Yu, Y., Zhang, Y., Zhang, Z., Yu, Y., & Zhao, X. (2019). Exogenous IL‐19 attenuates acute ischaemic injury and improves survival in male mice with myocardial infarction. British journal of pharmacology, 176(5), 699-710.

Weng, Y. H., Chen, W. Y., Lin, Y. L., Wang, J. Y., & Chang, M. S. (2019). Blocking IL-19 signaling ameliorates allergen-induced airway inflammation. Frontiers in Immunology, 10, 968.

Konrad, R. J., Higgs, R. E., Rodgers, G. H., Ming, W., Qian, Y. W., Bivi, N., ... & Nickoloff, B. J. (2019). Assessment and clinical relevance of serum IL-19 levels in psoriasis and atopic dermatitis using a sensitive and specific novel immunoassay. Scientific Reports, 9(1), 5211.

Ray, M., Gabunia, K., Vrakas, C. N., Herman, A. B., Kako, F., Kelemen, S. E., ... & Autieri, M. V. (2018). Genetic deletion of IL-19 (interleukin-19) exacerbates atherogenesis in Il19−/−× Ldlr−/− double knockout mice by dysregulation of mRNA stability protein HuR (human antigen R). Arteriosclerosis, thrombosis, and vascular biology, 38(6), 1297-1308.

Autieri, M. V. (2018). IL-19 and other IL-20 family member cytokines in vascular inflammatory diseases. Frontiers in Immunology, 9, 700.

Herman, A. B., Vrakas, C. N., Ray, M., Kelemen, S. E., Sweredoski, M. J., Moradian, A., ... & Autieri, M. V. (2018). FXR1 is an IL-19-responsive RNA-binding protein that destabilizes pro-inflammatory transcripts in vascular smooth muscle cells. Cell reports, 24(5), 1176-1189.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL19 protein, His Tag-1 (CAT#: V2LY-0526-LY4802)

Human Recombinant IL19 protein, His Tag-2 (CAT#: V2LY-0526-LY4803)

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Isotype control

For research use only. Not intended for any clinical use.

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