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Mouse Anti-IL32 Recombinant Antibody (B-B52) (CBMAB-I1973-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
B-B52
Antibody Isotype
IgG2b
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 32
Introduction
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Entrez Gene ID
9235
UniProt ID
P24001
Alternative Names
Interleukin 32
Function
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of viral life cycleIDA:ARUK-UCL
Positive regulation of gene expressionIDA:ARUK-UCL
Positive regulation of RNA polymerase II regulatory region sequence-specific DNA bindingIDA:ARUK-UCL
Positive regulation of type III interferon productionIDA:ARUK-UCL
Cellular Location
Secreted
More Infomation

Frost, B., Schmidt, M., Klein, B., Loeffler‐Wirth, H., Krohn, K., Reidenbach, T., ... & Kunz, M. (2023). Single‐cell transcriptomics reveals prominent expression of IL‐14, IL‐18, and IL‐32 in psoriasis. European Journal of Immunology, 2250354.

Sun, Y., Qian, Y., Chen, C., Wang, H., Zhou, X., Zhai, W., ... & Gao, Y. (2022). Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway. Journal of Experimental & Clinical Cancer Research, 41(1), 1-22.

Aass, K. R., Mjelle, R., Kastnes, M. H., Tryggestad, S. S., van den Brink, L. M., Roseth, I. A., ... & Standal, T. (2022). Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. Iscience, 25(1).

Aass, K. R., Kastnes, M. H., & Standal, T. (2021). Molecular interactions and functions of IL-32. Journal of Leucocyte Biology, 109(1), 143-159.

Gautam, A., & Pandit, B. (2021). IL32: The multifaceted and unconventional cytokine. Human Immunology, 82(9), 659-667.

Mazlum, F., Gharesi-Fard, B., Hadinedoushan, H., & Bakhshizadeh Ghashti, Y. (2021). Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsia. Hypertension in Pregnancy, 40(3), 218-225.

de Lima Silva, L. L., Gomes, R. S., Silva, M. V. T., Joosten, L. A., & Ribeiro-Dias, F. (2020). IL-15 enhances the capacity of primary human macrophages to control Leishmania braziliensis infection by IL-32/vitamin D dependent and independent pathways. Parasitology international, 76, 102097.

Wen, S., Hou, Y., Fu, L., Xi, L., Yang, D., Zhao, M., ... & Liu, M. (2019). Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3–p38 MAPK signalling. Cancer letters, 442, 320-332.

Dos Santos, J. C., de Figueiredo, A. M. B., Silva, M. V. T., Cirovic, B., de Bree, L. C. J., Damen, M. S., ... & Joosten, L. A. (2019). β-Glucan-induced trained immunity protects against Leishmania braziliensis infection: a crucial role for IL-32. Cell reports, 28(10), 2659-2672.

Sloot, Y. J., Smit, J. W., Joosten, L. A., & Netea-Maier, R. T. (2018, August). Insights into the role of IL-32 in cancer. In Seminars in immunology (Vol. 38, pp. 24-32). Academic Press.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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