IL32
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 32
Function
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of viral life cycleIDA:ARUK-UCL
Positive regulation of gene expressionIDA:ARUK-UCL
Positive regulation of RNA polymerase II regulatory region sequence-specific DNA bindingIDA:ARUK-UCL
Positive regulation of type III interferon productionIDA:ARUK-UCL
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of viral life cycleIDA:ARUK-UCL
Positive regulation of gene expressionIDA:ARUK-UCL
Positive regulation of RNA polymerase II regulatory region sequence-specific DNA bindingIDA:ARUK-UCL
Positive regulation of type III interferon productionIDA:ARUK-UCL
Cellular Location
Secreted
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Anti-IL32 antibodies
+ Filters

Target: IL32
Specificity: Human
Target: IL32
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A553
Application*: Dot blot, ELISA, WB
Target: IL32
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2I2
Application*: ELISA
Target: IL32
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1527
Application*: WB, E
Target: IL32
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I1471
Application*: WB
Target: IL32
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-K42
Application*: E
Target: IL32
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B-B52
Application*: E
Target: IL32
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT2F9
Application*: IF, E, WB
Target: IL32
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0206
Application*: WB, E, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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