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Mouse Anti-IRF2 Antibody (1B2) (CBMAB-0534-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B2
Antibody Isotype
IgG2a
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
IRF2 (interferon regulatory factor 2) is a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. Also, IRF2 acts as a transcriptional activator of histone H4.
Entrez Gene ID
3660
UniProt ID
P14316
Alternative Names
IRF-2
Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
PTM
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
More Infomation

Crossman, A. H., Ignatz, E. H., Hall, J. R., Kumar, S., Fast, M. D., Eslamloo, K., & Rise, M. L. (2023). Basal and immune-responsive transcript expression of two Atlantic salmon interferon regulatory factor 2 (irf2) paralogues. Developmental & Comparative Immunology, 143, 104689.

He, T., Yang, L., & Wu, D. (2022). Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide‐induced acute kidney injury. Drug Development Research, 83(4), 940-951.

Yan, Y., Zheng, L., Du, Q., Yan, B., & Geller, D. A. (2020). Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells. Cancer Immunology, Immunotherapy, 69, 1891-1903.

Zhu, K. C., Liu, B. S., Zhang, N., Guo, H. Y., Guo, L., Jiang, S. G., & Zhang, D. C. (2020). Interferon regulatory factor 2 plays a positive role in interferon gamma expression in golden pompano, Trachinotus ovatus (Linnaeus 1758). Fish & Shellfish Immunology, 96, 107-113.

Li, X., Zhou, C., Zhang, C., Xie, X., Zhou, Z., Zhou, M., ... & Ding, Z. (2019). MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon regulatory factor 2. Journal of Dermatological Science, 94(3), 330-338.

Jin, J. J., Liu, Y. H., Si, J. M., Ni, R., & Wang, J. (2018). Overexpression of miR-1290 contributes to cell proliferation and invasion of non small cell lung cancer by targeting interferon regulatory factor 2. The international journal of biochemistry & cell biology, 95, 113-120.

Cui, H., Banerjee, S., Guo, S., Xie, N., & Liu, G. (2018). IFN regulatory factor 2 inhibits expression of glycolytic genes and lipopolysaccharide-induced proinflammatory responses in macrophages. The Journal of Immunology, 200(9), 3218-3230.

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For research use only. Not intended for any clinical use.

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