IRF2

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
Full Name
interferon regulatory factor 2
Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
PTM
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
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Anti-IRF2 antibodies

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Mouse Anti-IRF2 Antibody (1B2) (CBMAB-0534-YC)

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Target: IRF2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B2
Application*: IP, M
Datasheet SDS

Mouse Anti-IRF2 Antibody (1A4) (CBMAB-0533-YC)

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Target: IRF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A4
Application*: IP, M
Datasheet SDS

Rabbit Anti-IRF2 Recombinant Antibody (EG1678) (CBMAB-EN2006-LY)

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Target: IRF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1678
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000
Datasheet SDS

IRF2 Matched Antibody Pair (645) (APMAB-645LY)

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Target: IRF2
Specificity: Human
Datasheet SDS

IRF2 Matched Antibody Pair (644) (APMAB-644LY)

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Target: IRF2
Specificity: Human
Datasheet SDS

Recombinant Rabbit Anti-IRF2 Antibody (CBAb137) (CBMAB-Ab137-LY)

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Target: IRF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb137
Application*: WB
Datasheet SDS

Mouse Anti-IRF2 Recombinant Antibody (3D6) (CBMAB-A4535-LY)

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Target: IRF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D6
Application*: WB, E
Datasheet SDS

Rabbit Anti-IRF2 Recombinant Antibody (CBYY-I1575) (CBMAB-I2745-YY)

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Target: IRF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-I1575
Application*: CI, F, IC, IF, P, WB
Datasheet SDS

Mouse Anti-IRF2 Recombinant Antibody (198C4a) (CBMAB-I0690-YY)

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Target: IRF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 198C4a
Application*: DB, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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