Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-IRF2 Recombinant Antibody (EG1678) (CBMAB-EN2006-LY)


See all IRF2 antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1678
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human IRF2.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
Entrez Gene ID
Human3660
Mouse16363
Rat290749
UniProt ID
HumanP14316
MouseP23906
RatQ0PXQ8
Alternative Names
IRF-2
Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
PTM
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
More Infomation

Crossman, A. H., Ignatz, E. H., Hall, J. R., Kumar, S., Fast, M. D., Eslamloo, K., & Rise, M. L. (2023). Basal and immune-responsive transcript expression of two Atlantic salmon interferon regulatory factor 2 (irf2) paralogues. Developmental & Comparative Immunology, 143, 104689.

He, T., Yang, L., & Wu, D. (2022). Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide‐induced acute kidney injury. Drug Development Research, 83(4), 940-951.

Yan, Y., Zheng, L., Du, Q., Yan, B., & Geller, D. A. (2020). Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells. Cancer Immunology, Immunotherapy, 69, 1891-1903.

Zhu, K. C., Liu, B. S., Zhang, N., Guo, H. Y., Guo, L., Jiang, S. G., & Zhang, D. C. (2020). Interferon regulatory factor 2 plays a positive role in interferon gamma expression in golden pompano, Trachinotus ovatus (Linnaeus 1758). Fish & Shellfish Immunology, 96, 107-113.

Li, X., Zhou, C., Zhang, C., Xie, X., Zhou, Z., Zhou, M., ... & Ding, Z. (2019). MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon regulatory factor 2. Journal of Dermatological Science, 94(3), 330-338.

Jin, J. J., Liu, Y. H., Si, J. M., Ni, R., & Wang, J. (2018). Overexpression of miR-1290 contributes to cell proliferation and invasion of non small cell lung cancer by targeting interferon regulatory factor 2. The international journal of biochemistry & cell biology, 95, 113-120.

Cui, H., Banerjee, S., Guo, S., Xie, N., & Liu, G. (2018). IFN regulatory factor 2 inhibits expression of glycolytic genes and lipopolysaccharide-induced proinflammatory responses in macrophages. The Journal of Immunology, 200(9), 3218-3230.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-IRF2 Recombinant Antibody (EG1678)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry