Mouse Anti-IRX5 Antibody (1B4) (CBMAB-0558-YC)

Name: Mouse Anti-IRX5 Antibody (1B4)
SKU: CBMAB-0558-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1B4

Application

IP, MA

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

IRX5

Introduction

IRX5 (iroquois homeobox 5) is a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. It has shown that IRX5 is required for retinal cone bipolar cell differentiation, and negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization.

Entrez Gene ID

10265

UniProt ID

P78411

Alternative Names

HMMS; IRXB2; IRX-2a

Function

Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity).
Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.

Biological Process

Cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Embryonic cranial skeleton morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Gonad developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to stimulusIEA:UniProtKB-KW
Visual perceptionIEA:UniProtKB-KW

Cellular Location

Nucleus

Involvement in disease

Hamamy syndrome (HMMS):
A syndrome characterized by severe hypertelorism, upslanting palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss, gonadal anomalies and borderline intelligence.

Kim, K. H., & Backx, P. H. (2021). Understanding the role of Iroquoi s homeobox transcription factor 5 (IRX5) in cardiac function: getting to the (human) heart of the matter. Cardiovascular Research, 117(9), 1989-1991.

Zhu, Z., Gong, J., Kong, J., Qian, Y., Lu, K., Wang, H., & Yu, M. (2021). Iroquois homeobox 5 negatively regulated by miRNA-147 promotes the proliferation, metastasis, and invasion by oral squamous cell carcinoma. Journal of Biomedical Nanotechnology, 17(6), 1098-1108.

Al Sayed, Z. R., Canac, R., Cimarosti, B., Bonnard, C., Gourraud, J. B., Hamamy, H., ... & Gaborit, N. (2021). Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction. Cardiovascular research, 117(9), 2092-2107.

Holmquist Mengelbier, L., Lindell‐Munther, S., Yasui, H., Jansson, C., Esfandyari, J., Karlsson, J., ... & Gisselsson, D. (2019). The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis. The Journal of pathology, 247(1), 86-98.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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