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Mouse Anti-IRX5 Antibody (1C11) (CBMAB-0559-YC)

Provided herein are mouse monoclonal antibodies against Human IRX5. The antibody clone 1C11 can be used for immunoassay techniques, such as IP, WB and MA.
See all IRX5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C11
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
IRX5
Introduction
IRX5 (iroquois homeobox 5) is a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. It has shown that IRX5 is required for retinal cone bipolar cell differentiation, and negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization.
Entrez Gene ID
10265
UniProt ID
P78411
Alternative Names
HMMS; IRXB2; IRX-2a
Function
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity).
Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
Biological Process
Cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Embryonic cranial skeleton morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Gonad developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to stimulusIEA:UniProtKB-KW
Visual perceptionIEA:UniProtKB-KW
Cellular Location
Nucleus
Involvement in disease
Hamamy syndrome (HMMS):
A syndrome characterized by severe hypertelorism, upslanting palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss, gonadal anomalies and borderline intelligence.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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