IRX5

IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM
Full Name
IRX5
Function
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity).
Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
Biological Process
Cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Embryonic cranial skeleton morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Gonad developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to stimulusIEA:UniProtKB-KW
Visual perceptionIEA:UniProtKB-KW
Cellular Location
Nucleus
Involvement in disease
Hamamy syndrome (HMMS):
A syndrome characterized by severe hypertelorism, upslanting palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss, gonadal anomalies and borderline intelligence.
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Anti-IRX5 antibodies

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Mouse Anti-IRX5 Recombinant Antibody (8A12) (CBMAB-A4556-LY)

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Target: IRX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 8A12
Application*: WB, E
Datasheet SDS

Mouse Anti-IRX5 Recombinant Antibody (3C11) (CBMAB-A4552-LY)

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Target: IRX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C11
Application*: WB, E
Datasheet SDS

Mouse Anti-IRX5 Recombinant Antibody (6B5) (CBMAB-I1550-YY)

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Target: IRX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6B5
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-IRX5 Recombinant Antibody (IRX5C10G5) (CBMAB-I0707-YY)

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Target: IRX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IRX5C10G5
Application*: DB, WB
Datasheet SDS

Mouse Anti-IRX5 Antibody (1C11) (CBMAB-0559-YC)

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Target: IRX5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1C11
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-IRX5 Antibody (1B4) (CBMAB-0558-YC)

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Target: IRX5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B4
Application*: IP, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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