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Mouse Anti-IRX5 Recombinant Antibody (3C11) (CBMAB-A4552-LY)

The product is antibody recognizes IRX5. The antibody 3C11 immunoassay techniques such as: WB, ELISA.
See all IRX5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C11
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
IRX5 (NP_005844, 204 a.a. ~ 264 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
IRX5
Introduction
IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM
Entrez Gene ID
10265
UniProt ID
P78411
Alternative Names
IRX-2a; IRXB2
Function
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity).
Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
Biological Process
Cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Embryonic cranial skeleton morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Gonad developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to stimulusIEA:UniProtKB-KW
Visual perceptionIEA:UniProtKB-KW
Cellular Location
Nucleus
Involvement in disease
Hamamy syndrome (HMMS):
A syndrome characterized by severe hypertelorism, upslanting palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss, gonadal anomalies and borderline intelligence.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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