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Rat Anti-ITLN1 Recombinant Antibody (CBYY-I0728) (CBMAB-I1625-YY)

This product is Rat antibody that recognizes ITLN1. The antibody CBYY-I0728 can be used for immunoassay techniques such as: WB, IHC
See all ITLN1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-I0728
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Intelectin 1
Introduction
ITLN1 (Intelectin 1) is a Protein Coding gene. Diseases associated with ITLN1 include Body Mass Index Quantitative Trait Locus 14 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Innate Immune System and Defensins.
Entrez Gene ID
16429
UniProt ID
O88310
Alternative Names
Intelectin 1
Function
Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048).
Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048).
Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048).
Does not bind human glycans (PubMed:26148048).
Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507).
Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507).
May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).
Biological Process
Positive regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB
Response to nematodeISS:UniProtKB
Cellular Location
Cell membrane; Secreted. Enriched in lipid rafts.
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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