ITLN1

ITLN1 (Intelectin 1) is a Protein Coding gene. Diseases associated with ITLN1 include Body Mass Index Quantitative Trait Locus 11 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN2.
Full Name
Intelectin 1
Function
Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048).
Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048).
Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048).
Does not bind human glycans (PubMed:26148048).
Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507).
Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507).
May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).
Biological Process
Positive regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB
Response to nematodeISS:UniProtKB
Cellular Location
Cell membrane; Secreted. Enriched in lipid rafts.
PTM
N-glycosylated.
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Anti-ITLN1 antibodies

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Human ITLN1 ELISA Kit (V2LY-0626-LY491)

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Target: ITLN1
Sensitivity: 0.001 ng/mL
Detection Range: 0.002-0.6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-ITLN1 Recombinant Antibody (A702) (CBMAB-AP4044LY)

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Target: ITLN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A702
Application*: Dot blot, ELISA, WB
Datasheet SDS

Mouse Anti-ITLN1 Recombinant Antibody (AT6C11) (CBMAB-I1928-YY)

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Target: ITLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT6C11
Application*: E, WB
Datasheet SDS

Rat Anti-ITLN1 Recombinant Antibody (CBYY-I0728) (CBMAB-I1625-YY)

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Target: ITLN1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0728
Application*: WB, IH
Datasheet SDS

Mouse Anti-ITLN1 Recombinant Antibody (CBYY-I0704) (CBMAB-I1553-YY)

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Target: ITLN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0704
Application*: WB, E
Datasheet SDS

Mouse Anti-ITLN1 Recombinant Antibody (Saly-2) (CBMAB-I1068-YY)

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Target: ITLN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: Saly-2
Application*: WB, E
Datasheet SDS

Mouse Anti-ITLN1 Recombinant Antibody (Saly-1) (CBMAB-O0423-CQ)

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Target: ITLN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: Saly-1
Application*: E, P, WB
Datasheet SDS

Mouse Anti-ITLN1 Recombinant Antibody (Lecty-1) (CBMAB-O0422-CQ)

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Target: ITLN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: Lecty-1
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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