Human ITLN1 ELISA Kit (V2LY-0626-LY491)

Name: Human ITLN1 ELISA Kit
SKU: V2LY-0626-LY491
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.001 ng/mL

Detection Range

0.002-0.6 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

35.0 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Intelectin 1

Function

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048).
Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048).
Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048).
Does not bind human glycans (PubMed:26148048).
Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507).
Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507).
May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).

Biological Process

Positive regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB
Response to nematodeISS:UniProtKB

Cellular Location

Cell membrane; Secreted. Enriched in lipid rafts.

PTM

N-glycosylated.

Nonnecke, E. B., Castillo, P. A., Akahoshi, D. T., Goley, S. M., Bevins, C. L., & Lönnerdal, B. (2022). Characterization of an intelectin-1 (Itln1) knockout mouse model. Frontiers in Immunology, 13, 894649.

Nonnecke, E. B., Castillo, P. A., Dugan, A. E., Almalki, F., Underwood, M. A., De La Motte, C. A., ... & Bevins, C. L. (2021). Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific reports, 11(1), 12889.

Chen, L., Jin, X. H., Luo, J., Duan, J. L., Cai, M. Y., Chen, J. W., ... & Xie, D. (2021). ITLN1 inhibits tumor neovascularization and myeloid derived suppressor cells accumulation in colorectal carcinoma. Oncogene, 40(40), 5925-5937.

Au-Yeung, C. L., Yeung, T. L., Achreja, A., Zhao, H., Yip, K. P., Kwan, S. Y., ... & Mok, S. C. (2020). ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment. Nature communications, 11(1), 3546.

Hamdy, N. M., & El-Shemy, R. A. (2020). Molecular Profiling of Breast Cancer Susceptibility of Obese or Insulin-Resistant and Pre-Diabetic Patients Using ITLN1 and CD295 SNPs. medRxiv, 2020-01.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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