Mouse Anti-ITLN1 Recombinant Antibody (Lecty-1) (CBMAB-O0422-CQ)

Name: Mouse Anti-ITLN1 Recombinant Antibody (Lecty-1)
SKU: CBMAB-O0422-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Lecty-1

Application

ELISA, WB

Immunogen

Recombinant human omentin 1 (intelectin-1)

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 10% glycerol

Preservative

0.02% Sodium Azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Intelectin 1

Introduction

ITLN1 (Intelectin 1) is a Protein Coding gene. Diseases associated with ITLN1 include Body Mass Index Quantitative Trait Locus 11 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN2.

Entrez Gene ID

55600

UniProt ID

Q8WWA0

Alternative Names

Intelectin

Function

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048).
Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048).
Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048).
Does not bind human glycans (PubMed:26148048).
Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507).
Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507).
May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).

Biological Process

Positive regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB
Response to nematodeISS:UniProtKB

Cellular Location

Cell membrane; Secreted. Enriched in lipid rafts.

PTM

N-glycosylated.

Nonnecke, E. B., Castillo, P. A., Akahoshi, D. T., Goley, S. M., Bevins, C. L., & Lönnerdal, B. (2022). Characterization of an intelectin-1 (Itln1) knockout mouse model. Frontiers in Immunology, 13, 894649.

Nonnecke, E. B., Castillo, P. A., Dugan, A. E., Almalki, F., Underwood, M. A., De La Motte, C. A., ... & Bevins, C. L. (2021). Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific reports, 11(1), 12889.

Chen, L., Jin, X. H., Luo, J., Duan, J. L., Cai, M. Y., Chen, J. W., ... & Xie, D. (2021). ITLN1 inhibits tumor neovascularization and myeloid derived suppressor cells accumulation in colorectal carcinoma. Oncogene, 40(40), 5925-5937.

Au-Yeung, C. L., Yeung, T. L., Achreja, A., Zhao, H., Yip, K. P., Kwan, S. Y., ... & Mok, S. C. (2020). ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment. Nature communications, 11(1), 3546.

Hamdy, N. M., & El-Shemy, R. A. (2020). Molecular Profiling of Breast Cancer Susceptibility of Obese or Insulin-Resistant and Pre-Diabetic Patients Using ITLN1 and CD295 SNPs. medRxiv, 2020-01.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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