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Mouse Anti-KIRREL2 Recombinant Antibody (2B9-1D3) (CBMAB-K0949-LY)

This product is antibody recognizes KIRREL2. The antibody 2B9-1D3 immunoassay techniques such as: ELISA, IP, WB.
See all KIRREL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B9-1D3
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
KIRREL2 (AAH07312, 1 a.a. ~ 219 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kirre Like Nephrin Family Adhesion Molecule 2
Introduction
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]
Entrez Gene ID
84063
UniProt ID
Q6UWL6
Alternative Names
Kirre Like Nephrin Family Adhesion Molecule 2; Kin Of Irregular Chiasm-Like Protein 2; Nephrin-Like Protein 3; NEPH3; Kin Of IRRE Like 2 (Drosophila); Kin Of IRRE-Like Protein 2;
Function
May regulate basal insulin secretion.
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of protein phosphorylationIEA:Ensembl
Cellular Location
Cell membrane. Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin.
Topology
Extracellular: 21-510
Helical: 511-531
Cytoplasmic: 532-708
PTM
N-glycosylated.
The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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