KIRREL2

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]
Full Name
Kirre Like Nephrin Family Adhesion Molecule 2
Function
May regulate basal insulin secretion.
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of protein phosphorylationIEA:Ensembl
Cellular Location
Cell membrane. Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin.
Topology
Extracellular: 21-510
Helical: 511-531
Cytoplasmic: 532-708
PTM
N-glycosylated.
The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.
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Anti-KIRREL2 antibodies

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Mouse Anti-KIRREL2 Recombinant Antibody (2B9-1D3) (CBMAB-K0949-LY)

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Target: KIRREL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B9-1D3
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-KIRREL2 Recombinant Antibody (G-12) (CBMAB-N0887-WJ)

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Target: KIRREL2
Host: Mouse
Specificity: Human
Clone: G-12
Application*: WB, IP, IF, E
Datasheet SDS

KIRREL2 Matched Antibody Pair (666) (APMAB-666LY)

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Target: KIRREL2
Specificity: Human
Datasheet SDS

KIRREL2 Matched Antibody Pair (665) (APMAB-665LY)

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Target: KIRREL2
Specificity: Human
Datasheet SDS

Mouse Anti-KIRREL2 Recombinant Antibody (318311) (CBMAB-K0950-LY)

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Target: KIRREL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 318311
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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