KIRREL2

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]

Kirre Like Nephrin Family Adhesion Molecule 2

May regulate basal insulin secretion.

Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of protein phosphorylationIEA:Ensembl

Cell membrane. Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin.

Extracellular: 21-510
Helical: 511-531
Cytoplasmic: 532-708

N-glycosylated.
The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.