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KIRREL2

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]

Full Name

Kirre Like Nephrin Family Adhesion Molecule 2

Function

May regulate basal insulin secretion.

Biological Process

Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of protein phosphorylationIEA:Ensembl

Cellular Location

Cell membrane. Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin.

Topology

Extracellular: 21-510
Helical: 511-531
Cytoplasmic: 532-708

PTM

N-glycosylated.
The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.

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Anti-KIRREL2 antibodies

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Mouse Anti-KIRREL2 Recombinant Antibody (2B9-1D3) (CBMAB-K0949-LY)

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Target: KIRREL2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B9-1D3

Application*: E, IP, WB

Mouse Anti-KIRREL2 Recombinant Antibody (G-12) (CBMAB-N0887-WJ)

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Target: KIRREL2

Host: Mouse

Specificity: Human

Clone: G-12

Application*: WB, IP, IF, E

Human Recombinant KIRREL2 protein, ECD, His Tag (V2LY-0526-LY5182)

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Target: KIRREL2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-503

Tag: His Tag

Human Recombinant KIRREL2 protein, ECD, hFc Tag (V2LY-0526-LY5181)

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Target: KIRREL2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-503

Tag: hFc Tag

KIRREL2 Matched Antibody Pair (666) (APMAB-666LY)

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Target: KIRREL2

Specificity: Human

KIRREL2 Matched Antibody Pair (665) (APMAB-665LY)

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Target: KIRREL2

Specificity: Human

Mouse Anti-KIRREL2 Recombinant Antibody (318311) (CBMAB-K0950-LY)

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Target: KIRREL2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 318311

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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