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Mouse Anti-KIRREL2 Recombinant Antibody (318311) (CBMAB-K0950-LY)

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Basic Information

Host Animal
Mouse
Clone
318311
Application
WB
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Kirrel2 Gly21-Arg503
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
5% trehalose
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Kirre Like Nephrin Family Adhesion Molecule 2
Introduction
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]
Entrez Gene ID
Human84063
Mouse243911
UniProt ID
HumanQ6UWL6
MouseQ7TSU7
Alternative Names
Kirre Like Nephrin Family Adhesion Molecule 2; Kin Of Irregular Chiasm-Like Protein 2; Nephrin-Like Protein 3; NEPH3; Kin Of IRRE Like 2 (Drosophila); Kin Of IRRE-Like Protein 2;
Function
May regulate basal insulin secretion.
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of protein phosphorylationIEA:Ensembl
Cellular Location
Cell membrane. Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin.
Topology
Extracellular: 21-510
Helical: 511-531
Cytoplasmic: 532-708
PTM
N-glycosylated.
The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.

Korshunov, A., Okonechnikov, K., Stichel, D., Schrimpf, D., Delaidelli, A., Tonn, S., ... & Kool, M. (2022). Gene expression profiling of Group 3 medulloblastomas defines a clinically tractable stratification based on KIRREL2 expression. Acta Neuropathologica, 144(2), 339-352.

Vaddadi, N., Iversen, K., Raja, R., Phen, A., Brignall, A., Dumontier, E., & Cloutier, J. F. (2019). Kirrel2 is differentially required in populations of olfactory sensory neurons for the targeting of axons in the olfactory bulb. Development, 146(11), dev173310.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

KIRREL2 Matched Antibody Pair (665) (CAT#: APMAB-665LY)

KIRREL2 Matched Antibody Pair (666) (CAT#: APMAB-666LY)

Related Products

KIRREL2 Matched Antibody Pair (665) (CAT#: APMAB-665LY)

Mouse Anti-KIRREL2 Recombinant Antibody (2B9-1D3) (CAT#: CBMAB-K0949-LY)

Mouse Anti-KIRREL2 Recombinant Antibody (G-12) (CAT#: CBMAB-N0887-WJ)

KIRREL2 Matched Antibody Pair (666) (CAT#: APMAB-666LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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