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Mouse Anti-KLHL2 Recombinant Antibody (1G7) (CBMAB-K1184-LY)

This product is antibody recognizes KLHL2. The antibody 1G7 immunoassay techniques such as: FC, IF, WB.
See all KLHL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Monkey
Clone
1G7
Antibody Isotype
IgG2b
Application
FC, IF, WB

Basic Information

Immunogen
KLHL2 antibody was raised in mouse using a human recombinant protein fragment corresponding to amino acids 1-100 and 494-593 of human KLHL2 (NP_009177) produced in HEK293T cells, as the immunogen
Specificity
Human, Dog, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg-1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kelch-like 2, Mayven (Drosophila)
Introduction
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Entrez Gene ID
Human11275
Monkey704790
Dog475490
UniProt ID
Alternative Names
Kelch Like Family Member 2; Actin-Binding Protein Mayven; Mayven; Kelch (Drosophila)-Like 2 (Mayven); Kelch-Like 2; Mayven (Drosophila); Kelch-Like 2; Mayven; Kelch-Like Protein 2; ABP-KELCH; MAV;
Function
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity).
Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Biological Process
Protein ubiquitinationISS:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton; Cell projection; Cytoplasm, cytosol. A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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