KLHL2

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Full Name
kelch-like 2, Mayven (Drosophila)
Function
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity).
Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Biological Process
Protein ubiquitinationISS:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton; Cell projection; Cytoplasm, cytosol. A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity).
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Anti-KLHL2 antibodies

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Mouse Anti-KLHL2 Recombinant Antibody (8D8) (CBMAB-K1189-LY)

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Target: KLHL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 8D8
Application*: WB
Datasheet SDS

Mouse Anti-KLHL2 Recombinant Antibody (8B8) (CBMAB-K1188-LY)

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Target: KLHL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8B8
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-KLHL2 Recombinant Antibody (6D8) (CBMAB-K1187-LY)

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Target: KLHL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6D8
Application*: F, IC/IF, WB
Datasheet SDS

Mouse Anti-KLHL2 Recombinant Antibody (3H9) (CBMAB-K1186-LY)

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Target: KLHL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H9
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-KLHL2 Recombinant Antibody (3G3) (CBMAB-K1185-LY)

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Target: KLHL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G3
Application*: E, WB
Datasheet SDS

Mouse Anti-KLHL2 Recombinant Antibody (1G7) (CBMAB-K1184-LY)

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Target: KLHL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Monkey
Clone: 1G7
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-KLHL2 Recombinant Antibody (10C12) (CBMAB-K1183-LY)

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Target: KLHL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10C12
Application*: F, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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