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Mouse Anti-KLK1 Recombinant Antibody (3G2) (CBMAB-K1205-LY)

This product is antibody recognizes KLK1. The antibody 3G2 immunoassay techniques such as: ELISA, WB.
See all KLK1 antibodies
Published Data
Fig. 1 Immunohistochemical staining for KLK in astrocytomas.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
KLK1 (AAH05313, 168 a.a. ~ 262 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: FPDDLQCVDL KILPNDECKK VHVQKVTDFM LCVGHLEGGK DTCVGDSGGP LMCDGVLQGV TSWGYVPCGT PNKPSVAVRV LSYVKWIEDT IAENS
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kallikrein 1
Introduction
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3816
UniProt ID
P06870
Alternative Names
Kallikrein 1; Kidney/Pancreas/Salivary Gland Kallikrein; Kallikrein 1; Renal/Pancreas/Salivary; Tissue Kallikrein; EC 3.4.21.35; Kallikrein Serine Protease 1; Glandular Kallikrein 1;
Function
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Biological Process
Regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Extracellular exosome
Nucleus
Secretory granule
PTM
The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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