Human Recombinant KLK1 protein, His Tag (V2LY-0526-LY5117)

Name: Human Recombinant KLK1 protein, His Tag
SKU: V2LY-0526-LY5117
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant KLK1 protein, His Tag consist of Amino Acid: 25-262 and predicts a molecular mass of 31.78 kDa.

Molecule Mass

31.78 kDa

Sequence

Amino Acid: 25-262

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

Sodium phosphate, NaCl, Imidazole, PMSF, DTT, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

kallikrein 1

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Biological Process

Regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Extracellular exosome
Nucleus
Secretory granule

PTM

The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.

Iwasaki, T., Tokumori, M., Matsubara, M., Ojima, F., Kamigochi, K., Aizawa, S., ... & Takahashi, S. (2023). A regulatory mechanism of mouse kallikrein 1 gene expression by estrogen. Molecular and cellular endocrinology, 577, 112044.

Zhang, M., Luo, C., Lin, D., Cui, K., Chen, Z., & Liu, J. (2021). Human tissue kallikrein 1 is downregulated in elderly human prostates and possesses potential in vitro antioxidative and antifibrotic effects in rodent prostates. Oxidative Medicine and Cellular Longevity, 2021.

Ma, L., Wu, J., Zheng, Y., Shu, Z., Wei, Z., Sun, Y., ... & Zhou, A. (2020). Heparin blocks the inhibition of tissue kallikrein 1 by kallistatin through electrostatic repulsion. Biomolecules, 10(6), 828.

Adamopoulos, P. G., Kontos, C. K., & Scorilas, A. (2019). Discovery of novel transcripts of the human tissue kallikrein (KLK1) and kallikrein-related peptidase 2 (KLK2) in human cancer cells, exploiting Next-Generation Sequencing technology. Genomics, 111(4), 642-652.

Devetzi, M., Goulielmaki, M., Khoury, N., Spandidos, D. A., Sotiropoulou, G., Christodoulou, I., & Zoumpourlis, V. (2018). Genetically‑modified stem cells in treatment of human diseases: Tissue kallikrein (KLK1)‑based targeted therapy. international journal of molecular medicine, 41(3), 1177-1186.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KLK1 protein, His Tag-1 (CAT#: V2LY-0526-LY5118)

Mouse Recombinant KLK1 protein, His Tag (CAT#: V2LY-0526-LY8583)

Human KLK1 ELISA Kit (CAT#: V2LY-0626-LY1126)

Mouse Klk1 ELISA Kit (CAT#: V2LY-0626-LY1640)

Mouse Klk1 ELISA Kit (2) (CAT#: V2LY-0626-LY2496)

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Human Recombinant KLK1 protein, His Tag-1 (CAT#: V2LY-0526-LY5118)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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