Mouse Anti-KLK1 Recombinant Antibody (5A6) (CBMAB-P0428-YC)

Name: Mouse Anti-KLK1 Recombinant Antibody (5A6)
SKU: CBMAB-P0428-YC
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

5A6

Antibody Isotype

IgG2a

Application

WB, ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

kallikrein 1

Introduction

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.

Entrez Gene ID

3816

UniProt ID

P06870

Alternative Names

Ngfg; mGk-3

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Biological Process

Regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Extracellular exosome
Nucleus
Secretory granule

PTM

The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.

More Infomation

References

Iwasaki, T., Tokumori, M., Matsubara, M., Ojima, F., Kamigochi, K., Aizawa, S., ... & Takahashi, S. (2023). A regulatory mechanism of mouse kallikrein 1 gene expression by estrogen. Molecular and cellular endocrinology, 577, 112044.

Zhang, M., Luo, C., Lin, D., Cui, K., Chen, Z., & Liu, J. (2021). Human tissue kallikrein 1 is downregulated in elderly human prostates and possesses potential in vitro antioxidative and antifibrotic effects in rodent prostates. Oxidative Medicine and Cellular Longevity, 2021.

Ma, L., Wu, J., Zheng, Y., Shu, Z., Wei, Z., Sun, Y., ... & Zhou, A. (2020). Heparin blocks the inhibition of tissue kallikrein 1 by kallistatin through electrostatic repulsion. Biomolecules, 10(6), 828.

Adamopoulos, P. G., Kontos, C. K., & Scorilas, A. (2019). Discovery of novel transcripts of the human tissue kallikrein (KLK1) and kallikrein-related peptidase 2 (KLK2) in human cancer cells, exploiting Next-Generation Sequencing technology. Genomics, 111(4), 642-652.

Devetzi, M., Goulielmaki, M., Khoury, N., Spandidos, D. A., Sotiropoulou, G., Christodoulou, I., & Zoumpourlis, V. (2018). Genetically‑modified stem cells in treatment of human diseases: Tissue kallikrein (KLK1)‑based targeted therapy. international journal of molecular medicine, 41(3), 1177-1186.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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