Sign in or Register   Sign in or Register
  |  

Mouse Anti-KLK7 Recombinant Antibody (CBLY1-124) (CBMAB-K1316-LY)

This product is antibody recognizes KLK7. The antibody CBLY1-124 immunoassay techniques such as: WB, IP, IF, ELISA.
See all KLK7 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBLY1-124
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kallikrein Related Peptidase 7
Introduction
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
Entrez Gene ID
Human5650
Mouse23993
Rat292852
UniProt ID
HumanP49862
MouseQ91VE3
RatP36373
Function
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
Biological Process
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Extracellular matrix disassemblyTAS:Reactome
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted 1 Publication
In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.

Xiang, F., Wang, Y., Cao, C., Li, Q., Deng, H., Zheng, J., ... & Tan, X. (2022). The role of kallikrein 7 in tumorigenesis. Current Medicinal Chemistry, 29(15), 2617-2631.

Kunath, A., Weiner, J., Krause, K., Rehders, M., Pejkovska, A., Gericke, M., ... & Blüher, M. (2021). Role of kallikrein 7 in body weight and fat mass regulation. Biomedicines, 9(2), 131.

Gong, W., Liu, Y., Diamandis, E. P., Kiechle, M., Bronger, H., Dorn, J., ... & Magdolen, V. (2020). Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer. Journal of Ovarian Research, 13, 1-9.

Guo, C. J., Mack, M. R., Oetjen, L. K., Trier, A. M., Council, M. L., Pavel, A. B., ... & Liu, Q. (2020). Kallikrein 7 promotes atopic dermatitis-associated itch independently of skin inflammation. Journal of Investigative Dermatology, 140(6), 1244-1252.

Silva, L. M., Kryza, T., Stoll, T., Hoogland, C., Dong, Y., Stephens, C. R., ... & Clements, J. A. (2019). Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome. Molecular & Cellular Proteomics, 18(5), 818-836.

Du, J. P., Li, L., Zheng, J., Zhang, D., Liu, W., Zheng, W. H., ... & Tan, X. (2018). Kallikrein-related peptidase 7 is a potential target for the treatment of pancreatic cancer. Oncotarget, 9(16), 12894.

Zieger, K., Weiner, J., Kunath, A., Gericke, M., Krause, K., Kern, M., ... & Heiker, J. T. (2018). Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo. Cellular and molecular life sciences, 75, 727-742.

Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., ... & Loessner, D. (2018). Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British journal of cancer, 119(7), 1-9.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-KLK7 Recombinant Antibody (CBLY1-124)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare