Human Recombinant KLK7 protein, His Tag (V2LY-0526-LY5127)

Name: Human Recombinant KLK7 protein, His Tag
SKU: V2LY-0526-LY5127
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant KLK7 protein, His Tag consist of Amino Acid: 1-253 and predicts a molecular mass of 26.7 kDa.

Molecule Mass

26.7 kDa

Sequence

Amino Acid: 1-253

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Hepes, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Kallikrein Related Peptidase 7

Function

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

Biological Process

Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Extracellular matrix disassemblyTAS:Reactome
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Secreted 1 Publication
In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.

Xiang, F., Wang, Y., Cao, C., Li, Q., Deng, H., Zheng, J., ... & Tan, X. (2022). The role of kallikrein 7 in tumorigenesis. Current Medicinal Chemistry, 29(15), 2617-2631.

Kunath, A., Weiner, J., Krause, K., Rehders, M., Pejkovska, A., Gericke, M., ... & Blüher, M. (2021). Role of kallikrein 7 in body weight and fat mass regulation. Biomedicines, 9(2), 131.

Gong, W., Liu, Y., Diamandis, E. P., Kiechle, M., Bronger, H., Dorn, J., ... & Magdolen, V. (2020). Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer. Journal of Ovarian Research, 13, 1-9.

Guo, C. J., Mack, M. R., Oetjen, L. K., Trier, A. M., Council, M. L., Pavel, A. B., ... & Liu, Q. (2020). Kallikrein 7 promotes atopic dermatitis-associated itch independently of skin inflammation. Journal of Investigative Dermatology, 140(6), 1244-1252.

Silva, L. M., Kryza, T., Stoll, T., Hoogland, C., Dong, Y., Stephens, C. R., ... & Clements, J. A. (2019). Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome. Molecular & Cellular Proteomics, 18(5), 818-836.

Du, J. P., Li, L., Zheng, J., Zhang, D., Liu, W., Zheng, W. H., ... & Tan, X. (2018). Kallikrein-related peptidase 7 is a potential target for the treatment of pancreatic cancer. Oncotarget, 9(16), 12894.

Zieger, K., Weiner, J., Kunath, A., Gericke, M., Krause, K., Kern, M., ... & Heiker, J. T. (2018). Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo. Cellular and molecular life sciences, 75, 727-742.

Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., ... & Loessner, D. (2018). Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British journal of cancer, 119(7), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KLK7 , Activated in vitro protein, ECD, His Tag (CAT#: V2LY-0526-LY5126)

Mouse Recombinant KLK7 protein, His Tag (CAT#: V2LY-0526-LY8585)

Human KLK7 ELISA Kit (CAT#: V2LY-0626-LY1098)

Related Products

Mouse Recombinant KLK7 protein, His Tag (CAT#: V2LY-0526-LY8585)

Human Recombinant KLK7 , Activated in vitro protein, ECD, His Tag (CAT#: V2LY-0526-LY5126)

Mouse Anti-KLK7 Recombinant Antibody (CBLY1-124) (CAT#: CBMAB-K1316-LY)

Mouse Anti-KLK7 Recombinant Antibody (MM0433-5J28) (CAT#: CBMAB-K1321-LY)

Mouse Anti-KLK7 Recombinant Antibody (5J28) (CAT#: CBMAB-K1319-LY)

Human KLK7 ELISA Kit (CAT#: V2LY-0626-LY1098)

Mouse Anti-KLK7 Recombinant Antibody (CBYC-P094) (CAT#: CBMAB-P0443-YC)

Mouse Anti-KLK7 Recombinant Antibody (F7) (CAT#: CBMAB-K1315-LY)

Mouse Anti-KLK7 Recombinant Antibody (F8) (CAT#: CBMAB-K1320-LY)

Isotype control

For research use only. Not intended for any clinical use.

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