Mouse Anti-KLK7 Recombinant Antibody (F8) (CBMAB-K1320-LY)

Name: Mouse Anti-KLK7 Recombinant Antibody (F8)
SKU: CBMAB-K1320-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to aa 21-253 of human kallikrein-7 (His-tagged)

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

10% glycerol

Preservative

0.05% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Kallikrein Related Peptidase 7

Introduction

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

Entrez Gene ID

5650

UniProt ID

P49862

Alternative Names

Kallikrein Related Peptidase 7; Kallikrein 7 (Chymotryptic; Stratum Corneum); Stratum Corneum Chymotryptic Enzyme; Serine Protease 6; PRSS6; SCCE; HK7;

Function

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

Biological Process

Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Extracellular matrix disassemblyTAS:Reactome
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Secreted 1 Publication
In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.

Xiang, F., Wang, Y., Cao, C., Li, Q., Deng, H., Zheng, J., ... & Tan, X. (2022). The role of kallikrein 7 in tumorigenesis. Current Medicinal Chemistry, 29(15), 2617-2631.

Kunath, A., Weiner, J., Krause, K., Rehders, M., Pejkovska, A., Gericke, M., ... & Blüher, M. (2021). Role of kallikrein 7 in body weight and fat mass regulation. Biomedicines, 9(2), 131.

Gong, W., Liu, Y., Diamandis, E. P., Kiechle, M., Bronger, H., Dorn, J., ... & Magdolen, V. (2020). Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer. Journal of Ovarian Research, 13, 1-9.

Guo, C. J., Mack, M. R., Oetjen, L. K., Trier, A. M., Council, M. L., Pavel, A. B., ... & Liu, Q. (2020). Kallikrein 7 promotes atopic dermatitis-associated itch independently of skin inflammation. Journal of Investigative Dermatology, 140(6), 1244-1252.

Silva, L. M., Kryza, T., Stoll, T., Hoogland, C., Dong, Y., Stephens, C. R., ... & Clements, J. A. (2019). Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome. Molecular & Cellular Proteomics, 18(5), 818-836.

Du, J. P., Li, L., Zheng, J., Zhang, D., Liu, W., Zheng, W. H., ... & Tan, X. (2018). Kallikrein-related peptidase 7 is a potential target for the treatment of pancreatic cancer. Oncotarget, 9(16), 12894.

Zieger, K., Weiner, J., Kunath, A., Gericke, M., Krause, K., Kern, M., ... & Heiker, J. T. (2018). Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo. Cellular and molecular life sciences, 75, 727-742.

Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., ... & Loessner, D. (2018). Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British journal of cancer, 119(7), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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