Human KLK7 ELISA Kit (V2LY-0626-LY1098)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.16 ng/mL
Detection Range
0.3-90 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
27.5 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Kallikrein Related Peptidase 7
Function
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
Biological Process
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Extracellular matrix disassemblyTAS:Reactome
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted 1 Publication
In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.

Xiang, F., Wang, Y., Cao, C., Li, Q., Deng, H., Zheng, J., ... & Tan, X. (2022). The role of kallikrein 7 in tumorigenesis. Current Medicinal Chemistry, 29(15), 2617-2631.

Kunath, A., Weiner, J., Krause, K., Rehders, M., Pejkovska, A., Gericke, M., ... & Blüher, M. (2021). Role of kallikrein 7 in body weight and fat mass regulation. Biomedicines, 9(2), 131.

Gong, W., Liu, Y., Diamandis, E. P., Kiechle, M., Bronger, H., Dorn, J., ... & Magdolen, V. (2020). Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer. Journal of Ovarian Research, 13, 1-9.

Guo, C. J., Mack, M. R., Oetjen, L. K., Trier, A. M., Council, M. L., Pavel, A. B., ... & Liu, Q. (2020). Kallikrein 7 promotes atopic dermatitis-associated itch independently of skin inflammation. Journal of Investigative Dermatology, 140(6), 1244-1252.

Silva, L. M., Kryza, T., Stoll, T., Hoogland, C., Dong, Y., Stephens, C. R., ... & Clements, J. A. (2019). Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome. Molecular & Cellular Proteomics, 18(5), 818-836.

Du, J. P., Li, L., Zheng, J., Zhang, D., Liu, W., Zheng, W. H., ... & Tan, X. (2018). Kallikrein-related peptidase 7 is a potential target for the treatment of pancreatic cancer. Oncotarget, 9(16), 12894.

Zieger, K., Weiner, J., Kunath, A., Gericke, M., Krause, K., Kern, M., ... & Heiker, J. T. (2018). Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo. Cellular and molecular life sciences, 75, 727-742.

Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., ... & Loessner, D. (2018). Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British journal of cancer, 119(7), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KLK7 , Activated in vitro protein, ECD, His Tag (CAT#: V2LY-0526-LY5126)

Human Recombinant KLK7 protein, His Tag (CAT#: V2LY-0526-LY5127)

Mouse Recombinant KLK7 protein, His Tag (CAT#: V2LY-0526-LY8585)

Related Products

Human Recombinant KLK7 , Activated in vitro protein, ECD, His Tag (CAT#: V2LY-0526-LY5126)

Mouse Anti-KLK7 Recombinant Antibody (F7) (CAT#: CBMAB-K1315-LY)

Mouse Anti-KLK7 Recombinant Antibody (5J28) (CAT#: CBMAB-K1319-LY)

Mouse Anti-KLK7 Recombinant Antibody (MM0433-5J28) (CAT#: CBMAB-K1321-LY)

Mouse Anti-KLK7 Recombinant Antibody (CBYC-P094) (CAT#: CBMAB-P0443-YC)

Human Recombinant KLK7 protein, His Tag (CAT#: V2LY-0526-LY5127)

Mouse Recombinant KLK7 protein, His Tag (CAT#: V2LY-0526-LY8585)

Mouse Anti-KLK7 Recombinant Antibody (F8) (CAT#: CBMAB-K1320-LY)

Mouse Anti-KLK7 Recombinant Antibody (CBLY1-124) (CAT#: CBMAB-K1316-LY)

Isotype control

For research use only. Not intended for any clinical use.

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