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Rabbit Anti-LAIR2 Recombinant Antibody (CBYJL-1067) (CBMAB-L0500-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2). The antibody can be used for immunoassay techniques, such as ELISA(Cap).
See all LAIR2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJL-1067
Antibody Isotype
IgG
Application
ELISA(Cap)

Basic Information

Immunogen
Recombinant Human LAIR2 (CD306) Protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leukocyte associated immunoglobulin like receptor 2
Introduction
LAIR2 is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. LAIR2 is a soluble receptor that may function in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
3904
UniProt ID
Q6ISS4
Cellular Location
Secreted

Elsayed, O. M., Abdelazim, S. A., Darwish, H. A., Shaker, O. G., & Senousy, M. A. (2023). Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism. Scientific Reports, 13(1), 6.

Pan, B., Wang, Z., Yao, Y., Ke, X., Shen, S., Chen, W., ... & Tang, N. (2023). TGF-β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma. Cellular Oncology, 1-20.

Wang, P., Zhuang, W., Zheng, Z., Zhang, L., Zhang, X., & Chen, Q. (2023). Dissecting T-cell heterogeneity in esophageal squamous cell carcinoma reveals the potential role of LAIR2 in antitumor immunity. Clinical and Experimental Immunology, 214(1), 36-49.

Ly, D., Li, Q., Navab, R., Zeltz, C., Fang, L., Cabanero, M., ... & Zhang, L. (2022). Tumor-associated regulatory T cell expression of LAIR2 is prognostic in lung adenocarcinoma. Cancers, 14(1), 205.

Ramos, M. I. P., Tian, L., de Ruiter, E. J., Song, C., Paucarmayta, A., Singh, A., ... & Meyaard, L. (2021). Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction. Elife, 10, e62927.

Chen, Z., Yu, M., Yan, J., Guo, L., Zhang, B., Liu, S., ... & Xiao, Y. (2021). PNOC expressed by B cells in cholangiocarcinoma was survival related and LAIR2 could be a T cell exhaustion biomarker in tumor microenvironment: characterization of immune microenvironment combining single-cell and bulk sequencing technology. Frontiers in Immunology, 12, 647209.

Myint, H., Tian, L., Shaik, J., Barbu, E., Zhou, Q., Morawski, A., ... & Langermann, S. (2021). 487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors.

Horn, L., Tian, L., Flies, D., Liu, L., Langermann, S., Schlom, J., & Palena, C. (2020). 445 Blockade of the inhibitory collagen receptor LAIR-1 with NC410, a LAIR2-Fc fusion protein, enhances anti-tumor activity of the bifunctional fusion protein bintrafusp alfa.

Ly, D., Cabanero, M., Zhu, C., Tsao, M., & Zhang, L. (2018). P1. 04-05 elucidating the role of leukocyte-associated immunoglobin-like receptor 2 (LAIR2) in lung cancer development. Journal of Thoracic Oncology, 13(10), S526-S527.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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