Human Recombinant LAIR2 protein (V2LY-0526-LY5244)

Name: Human Recombinant LAIR2 protein
SKU: V2LY-0526-LY5244
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Protein Construction

This product is Human Recombinant LAIR2 protein consist of Amino Acid: 1-152 and predicts a molecular mass of 14.1 kDa.

Molecule Mass

14.1 kDa

Verified

HPLC

Sequence

Amino Acid: 1-152

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥93% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

leukocyte associated immunoglobulin like receptor 2

Cellular Location

Secreted

Elsayed, O. M., Abdelazim, S. A., Darwish, H. A., Shaker, O. G., & Senousy, M. A. (2023). Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism. Scientific Reports, 13(1), 6.

Pan, B., Wang, Z., Yao, Y., Ke, X., Shen, S., Chen, W., ... & Tang, N. (2023). TGF-β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma. Cellular Oncology, 1-20.

Wang, P., Zhuang, W., Zheng, Z., Zhang, L., Zhang, X., & Chen, Q. (2023). Dissecting T-cell heterogeneity in esophageal squamous cell carcinoma reveals the potential role of LAIR2 in antitumor immunity. Clinical and Experimental Immunology, 214(1), 36-49.

Ly, D., Li, Q., Navab, R., Zeltz, C., Fang, L., Cabanero, M., ... & Zhang, L. (2022). Tumor-associated regulatory T cell expression of LAIR2 is prognostic in lung adenocarcinoma. Cancers, 14(1), 205.

Ramos, M. I. P., Tian, L., de Ruiter, E. J., Song, C., Paucarmayta, A., Singh, A., ... & Meyaard, L. (2021). Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction. Elife, 10, e62927.

Chen, Z., Yu, M., Yan, J., Guo, L., Zhang, B., Liu, S., ... & Xiao, Y. (2021). PNOC expressed by B cells in cholangiocarcinoma was survival related and LAIR2 could be a T cell exhaustion biomarker in tumor microenvironment: characterization of immune microenvironment combining single-cell and bulk sequencing technology. Frontiers in Immunology, 12, 647209.

Myint, H., Tian, L., Shaik, J., Barbu, E., Zhou, Q., Morawski, A., ... & Langermann, S. (2021). 487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors.

Horn, L., Tian, L., Flies, D., Liu, L., Langermann, S., Schlom, J., & Palena, C. (2020). 445 Blockade of the inhibitory collagen receptor LAIR-1 with NC410, a LAIR2-Fc fusion protein, enhances anti-tumor activity of the bifunctional fusion protein bintrafusp alfa.

Ly, D., Cabanero, M., Zhu, C., Tsao, M., & Zhang, L. (2018). P1. 04-05 elucidating the role of leukocyte-associated immunoglobin-like receptor 2 (LAIR2) in lung cancer development. Journal of Thoracic Oncology, 13(10), S526-S527.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LAIR2 protein, His Tag (CAT#: V2LY-0526-LY5243)

Human Recombinant LAIR2 protein-1 (CAT#: V2LY-0526-LY5245)

Human LAIR2 ELISA Kit (CAT#: V2LY-0626-LY2772)

Human LAIR2 ELISA Kit (2) (CAT#: V2LY-0626-LY4812)

Related Products

Rabbit Anti-LAIR2 Recombinant Antibody (CBYJL-1067) (CAT#: CBMAB-L0500-YJ)

Human Recombinant LAIR2 protein, His Tag (CAT#: V2LY-0526-LY5243)

Mouse Anti-LAIR2 Recombinant Antibody (319701) (CAT#: CBMAB-L0502-YJ)

Mouse Anti-LAIR2 Recombinant Antibody (CBT2196) (CAT#: V2LY-0625-LY1272)

Mouse Anti-LAIR2 Recombinant Antibody (24) (CAT#: CBMAB-L0501-YJ)

Human Recombinant LAIR2 protein-1 (CAT#: V2LY-0526-LY5245)

Mouse Anti-LAIR2 Recombinant Antibody (CBYJL-1068) (CAT#: CBMAB-L0504-YJ)

Human LAIR2 ELISA Kit (CAT#: V2LY-0626-LY2772)

Human LAIR2 ELISA Kit (2) (CAT#: V2LY-0626-LY4812)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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