Mouse Anti-LAYN Recombinant Antibody (CBYJL-1232) (CBMAB-L0754-YJ)

Name: Mouse Anti-LAYN Recombinant Antibody (CBYJL-1232)
SKU: CBMAB-L0754-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1232

Application

ELISA

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, 5% trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 22-220

More Infomation

Target

Full Name

layilin

Introduction

Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hyaluronic acid binding. LAYN is an important paralog of this gene is CHODL. Receptor for hyaluronate.

Entrez Gene ID

143903

UniProt ID

Q6UX15

Function

Receptor for hyaluronate.

Cellular Location

Membrane
Colocalizes with TLN1 at the membrane ruffles.

Topology

Extracellular: 22-235
Helical: 236-256
Cytoplasmic: 257-382

Liu, C., Wang, Y., Zhang, Y. H., Yuan, Z., Zhang, Z., Zeng, X., ... & Lu, S. (2023). Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status. Immunological Investigations, 52(7), 879-896.

Yang, Y., Chen, Z., Chu, X., Yan, Q., He, J., Guo, Y., ... & Pan, J. (2023). Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides. Matrix Biology, 117, 15-30.

Yang, B., Deng, B., Jiao, X. D., Qin, B. D., Lu, Y., Zhang, W., ... & Zang, Y. S. (2022). Low-dose anti-VEGFR2 therapy promotes anti-tumor immunity in lung adenocarcinoma by down-regulating the expression of layilin on tumor-infiltrating CD8+ T cells. Cellular Oncology, 45(6), 1297-1309.

Li, L., Ma, H., & Song, C. (2022). LAYN acts as a prognostic biomarker in ovarian cancer by engaging T cell exclusion and dysfunction.

Cao, L., Zhu, L., & Cheng, L. (2022). ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis. BioMed Research International, 2022.

Mehta, P., Gouirand, V., Boda, D. P., Zhang, J., Gearty, S. V., Zirak, B., ... & Rosenblum, M. D. (2021). Layilin anchors regulatory T cells in skin. The Journal of Immunology, 207(7), 1763-1775.

Mahuron, K. M., Moreau, J. M., Glasgow, J. E., Boda, D. P., Pauli, M. L., Gouirand, V., ... & Rosenblum, M. D. (2020). Layilin augments integrin activation to promote antitumor immunity. Journal of Experimental Medicine, 217(9).

Pan, J. H., Zhou, H., Cooper, L., Huang, J. L., Zhu, S. B., Zhao, X. X., ... & Rong, L. (2019). LAYN is a prognostic biomarker and correlated with immune infiltrates in gastric and colon cancers. Frontiers in immunology, 10, 6.

Kim, Y., West, G. A., Ray, G., Kessler, S. P., Petrey, A. C., Fiocchi, C., ... & de la Motte, C. A. (2018). Layilin is critical for mediating hyaluronan 35 kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo. Matrix Biology, 66, 93-109.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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