Human LAYN ELISA Kit (V2LY-0626-LY3433)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.005 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
43.1 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
layilin
Function
Receptor for hyaluronate.
Cellular Location
Membrane
Colocalizes with TLN1 at the membrane ruffles.
Topology
Extracellular: 22-235
Helical: 236-256
Cytoplasmic: 257-382

Liu, C., Wang, Y., Zhang, Y. H., Yuan, Z., Zhang, Z., Zeng, X., ... & Lu, S. (2023). Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status. Immunological Investigations, 52(7), 879-896.

Yang, Y., Chen, Z., Chu, X., Yan, Q., He, J., Guo, Y., ... & Pan, J. (2023). Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides. Matrix Biology, 117, 15-30.

Yang, B., Deng, B., Jiao, X. D., Qin, B. D., Lu, Y., Zhang, W., ... & Zang, Y. S. (2022). Low-dose anti-VEGFR2 therapy promotes anti-tumor immunity in lung adenocarcinoma by down-regulating the expression of layilin on tumor-infiltrating CD8+ T cells. Cellular Oncology, 45(6), 1297-1309.

Li, L., Ma, H., & Song, C. (2022). LAYN acts as a prognostic biomarker in ovarian cancer by engaging T cell exclusion and dysfunction.

Cao, L., Zhu, L., & Cheng, L. (2022). ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis. BioMed Research International, 2022.

Mehta, P., Gouirand, V., Boda, D. P., Zhang, J., Gearty, S. V., Zirak, B., ... & Rosenblum, M. D. (2021). Layilin anchors regulatory T cells in skin. The Journal of Immunology, 207(7), 1763-1775.

Mahuron, K. M., Moreau, J. M., Glasgow, J. E., Boda, D. P., Pauli, M. L., Gouirand, V., ... & Rosenblum, M. D. (2020). Layilin augments integrin activation to promote antitumor immunity. Journal of Experimental Medicine, 217(9).

Pan, J. H., Zhou, H., Cooper, L., Huang, J. L., Zhu, S. B., Zhao, X. X., ... & Rong, L. (2019). LAYN is a prognostic biomarker and correlated with immune infiltrates in gastric and colon cancers. Frontiers in immunology, 10, 6.

Kim, Y., West, G. A., Ray, G., Kessler, S. P., Petrey, A. C., Fiocchi, C., ... & de la Motte, C. A. (2018). Layilin is critical for mediating hyaluronan 35 kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo. Matrix Biology, 66, 93-109.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LAYN protein, hFc Tag (CAT#: V2LY-0526-LY5257)

Human Recombinant LAYN protein, His Tag (CAT#: V2LY-0526-LY5258)

Rat Recombinant LAYN protein (CAT#: V2LY-0526-LY9505)

Rat Recombinant LAYN protein, hFc Tag (CAT#: V2LY-0526-LY9506)

Rat Recombinant LAYN protein, His Tag (CAT#: V2LY-0526-LY9507)

Rhesus Recombinant LAYN protein, hFc Tag (CAT#: V2LY-0526-LY9765)

Rhesus Recombinant LAYN protein, His Tag (CAT#: V2LY-0526-LY9766)

Related Products

Rhesus Recombinant LAYN protein, hFc Tag (CAT#: V2LY-0526-LY9765)

Mouse Anti-LAYN Recombinant Antibody (CBYJL-1224) (CAT#: CBMAB-L0741-YJ)

Mouse Anti-LAYN Recombinant Antibody (MM0448-4F33) (CAT#: CBMAB-L0753-YJ)

Human Recombinant LAYN protein, His Tag (CAT#: V2LY-0526-LY5258)

Mouse Anti-LAYN Recombinant Antibody (CBYJL-1222) (CAT#: CBMAB-L0739-YJ)

Mouse Anti-LAYN Recombinant Antibody (3F7D7E2) (CAT#: CBMAB-L0746-YJ)

Rat Recombinant LAYN protein (CAT#: V2LY-0526-LY9505)

Human Recombinant LAYN protein, hFc Tag (CAT#: V2LY-0526-LY5257)

Mouse Anti-LAYN Recombinant Antibody (CBYJL-1223) (CAT#: CBMAB-L0740-YJ)

Mouse Anti-LAYN Recombinant Antibody (CBYJL-1232) (CAT#: CBMAB-L0754-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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