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Rabbit Anti-LGMN Recombinant Antibody (D6S4H) (CBMAB-CP1379-LY)

The product is antibody recognizes LGMN. The antibody D6S4H immunoassay techniques such as: WB,IHC-P.
See all LGMN antibodies
Published Data
Fig.1 Legumain, cathepsin B and L expressions in cytosolic and membrane fractions of myotubes.
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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D6S4H
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu251 of human Legumain protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LGMN
Entrez Gene ID
Human5641
Mouse19141
Rat63865
UniProt ID
HumanQ99538
MouseO89017
RatQ9R0J8
Function
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity).
May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Biological Process
Activation of cysteine-type endopeptidase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Antigen processing and presentation of exogenous peptide antigen via MHC class IITAS:Reactome
Associative learningBy SimilarityISS:ARUK-UCL
Cellular response to amyloid-betaManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular response to calcium ionManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular response to hepatocyte growth factor stimulusManual Assertion Based On ExperimentIDA:ARUK-UCL
Dendritic spine organizationBy SimilarityISS:ARUK-UCL
MemoryBy SimilarityISS:ARUK-UCL
Negative regulation of ERBB signaling pathwayISS:UniProtKB
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of multicellular organism growthIEA:Ensembl
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIGI:MGI
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of endothelial cell chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of long-term synaptic potentiationBy SimilarityISS:ARUK-UCL
Positive regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of monocyte chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
ProteolysisBy SimilarityISS:UniProtKB
Proteolysis involved in cellular protein catabolic processISS:UniProtKB
Receptor catabolic processISS:UniProtKB
Renal system processISS:UniProtKB
Response to acidic pHManual Assertion Based On ExperimentIDA:ARUK-UCL
Self proteolysisManual Assertion Based On ExperimentIDA:ARUK-UCL
Vacuolar protein processingManual Assertion Based On ExperimentIBA:GO_Central
Vitamin D metabolic processTAS:Reactome
Cellular Location
Lysosome
PTM
Glycosylated.
Activated by autocatalytic processing at pH 4.

Ke, B. Y., Qin, Y. S., Cheng, L., & Wang, S. Z. (2023). Legumain: a potential biomarker for atherosclerosis. Journal of Pharmacy and Pharmacology, 75(11), 1395-1404.

Ehsan, M., Hu, R. S., Wang, M., Hou, J. L., Rashid, M., & Malik, M. I. (2023). Immune modulation of goat monocytes by Fasciola gigantica Legumain-1 protein (Fg-LGMN-1). Experimental Parasitology, 108671.

He, Y., Zou, P., Lu, J., Lu, Y., Yuan, S., Zheng, X., ... & Zhou, S. (2023). CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6. Circulation Research.

Pan, L., Bai, P., Weng, X., Liu, J., Chen, Y., Chen, S., ... & Ge, J. (2022). Legumain is an endogenous modulator of integrin αvβ3 triggering vascular degeneration, dissection, and rupture. Circulation, 145(9), 659-674.

Liu, C., Wang, J., Zheng, Y., Zhu, Y., Zhou, Z., Liu, Z., ... & Chen, J. (2022). Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3. Oncogene, 41(34), 4091-4103.

Jia, D., Chen, S., Bai, P., Luo, C., Liu, J., Sun, A., & Ge, J. (2022). Cardiac resident macrophage-derived legumain improves cardiac repair by promoting clearance and degradation of apoptotic cardiomyocytes after myocardial infarction. Circulation, 145(20), 1542-1556.

Reddy, B. D., Beeraka, N. M., Chitturi, C. H., & Madhunapantula, S. V. (2021). An overview of targeting legumain for inhibiting cancers. Current Pharmaceutical Design, 27(31), 3337-3348.

Wang, H., Chen, B., Lin, Y., Zhou, Y., & Li, X. (2020). Legumain promotes gastric cancer progression through tumor-associated macrophages in vitro and in vivo. International Journal of Biological Sciences, 16(1), 172.

Ren, Y. C., Zhao, Q., He, Y., Li, B., Wu, Z., Dai, J., ... & Hu, G. (2020). Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor β1. Journal of Molecular Medicine, 98, 863-874.

Wang, Y., Zhang, S., Wang, H., Cui, Y., Wang, Z., Cheng, X., ... & Liu, T. (2020). High level of legumain was correlated with worse prognosis and peritoneal metastasis in gastric cancer patients. Frontiers in Oncology, 10, 966.

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For research use only. Not intended for any clinical use.

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