Mouse Recombinant LGMN protein, His Tag (V2LY-0526-LY8613)

Name: Mouse Recombinant LGMN protein, His Tag
SKU: V2LY-0526-LY8613
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant LGMN protein, His Tag consist of Amino Acid: 18-435 and predicts a molecular mass of 49.8 kDa.

Molecule Mass

49.8 kDa

Verified

HPLC

Sequence

Amino Acid: 18-435

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥75% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Sodium Citrate, NaCl, Glycerol, Trehalose

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

LGMN

Function

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity).
May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

Biological Process

Activation of cysteine-type endopeptidase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Antigen processing and presentation of exogenous peptide antigen via MHC class IITAS:Reactome
Associative learningBy SimilarityISS:ARUK-UCL
Cellular response to amyloid-betaManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular response to calcium ionManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular response to hepatocyte growth factor stimulusManual Assertion Based On ExperimentIDA:ARUK-UCL
Dendritic spine organizationBy SimilarityISS:ARUK-UCL
MemoryBy SimilarityISS:ARUK-UCL
Negative regulation of ERBB signaling pathwayISS:UniProtKB
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of multicellular organism growthIEA:Ensembl
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIGI:MGI
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of endothelial cell chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of long-term synaptic potentiationBy SimilarityISS:ARUK-UCL
Positive regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of monocyte chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
ProteolysisBy SimilarityISS:UniProtKB
Proteolysis involved in cellular protein catabolic processISS:UniProtKB
Receptor catabolic processISS:UniProtKB
Renal system processISS:UniProtKB
Response to acidic pHManual Assertion Based On ExperimentIDA:ARUK-UCL
Self proteolysisManual Assertion Based On ExperimentIDA:ARUK-UCL
Vacuolar protein processingManual Assertion Based On ExperimentIBA:GO_Central
Vitamin D metabolic processTAS:Reactome

Cellular Location

Lysosome

PTM

Glycosylated.
Activated by autocatalytic processing at pH 4.

Ke, B. Y., Qin, Y. S., Cheng, L., & Wang, S. Z. (2023). Legumain: a potential biomarker for atherosclerosis. Journal of Pharmacy and Pharmacology, 75(11), 1395-1404.

Ehsan, M., Hu, R. S., Wang, M., Hou, J. L., Rashid, M., & Malik, M. I. (2023). Immune modulation of goat monocytes by Fasciola gigantica Legumain-1 protein (Fg-LGMN-1). Experimental Parasitology, 108671.

He, Y., Zou, P., Lu, J., Lu, Y., Yuan, S., Zheng, X., ... & Zhou, S. (2023). CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6. Circulation Research.

Pan, L., Bai, P., Weng, X., Liu, J., Chen, Y., Chen, S., ... & Ge, J. (2022). Legumain is an endogenous modulator of integrin αvβ3 triggering vascular degeneration, dissection, and rupture. Circulation, 145(9), 659-674.

Liu, C., Wang, J., Zheng, Y., Zhu, Y., Zhou, Z., Liu, Z., ... & Chen, J. (2022). Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3. Oncogene, 41(34), 4091-4103.

Jia, D., Chen, S., Bai, P., Luo, C., Liu, J., Sun, A., & Ge, J. (2022). Cardiac resident macrophage-derived legumain improves cardiac repair by promoting clearance and degradation of apoptotic cardiomyocytes after myocardial infarction. Circulation, 145(20), 1542-1556.

Reddy, B. D., Beeraka, N. M., Chitturi, C. H., & Madhunapantula, S. V. (2021). An overview of targeting legumain for inhibiting cancers. Current Pharmaceutical Design, 27(31), 3337-3348.

Wang, H., Chen, B., Lin, Y., Zhou, Y., & Li, X. (2020). Legumain promotes gastric cancer progression through tumor-associated macrophages in vitro and in vivo. International Journal of Biological Sciences, 16(1), 172.

Ren, Y. C., Zhao, Q., He, Y., Li, B., Wu, Z., Dai, J., ... & Hu, G. (2020). Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor β1. Journal of Molecular Medicine, 98, 863-874.

Wang, Y., Zhang, S., Wang, H., Cui, Y., Wang, Z., Cheng, X., ... & Liu, T. (2020). High level of legumain was correlated with worse prognosis and peritoneal metastasis in gastric cancer patients. Frontiers in Oncology, 10, 966.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

LGMN Matched Antibody Pair (689) (CAT#: APMAB-689LY)

Human Recombinant LGMN protein, His Tag (CAT#: V2LY-0526-LY5280)

Sus scrofa (Pig) Recombinant LGMN protein, His Tag (CAT#: V2LY-0526-LY9837)

Sus scrofa (Pig) Recombinant LGMN protein, His Tag-1 (CAT#: V2LY-0526-LY9838)

Antibody Pairs

LGMN Matched Antibody Pair (689) (CAT#: APMAB-689LY)

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Sus scrofa (Pig) Recombinant LGMN protein, His Tag-1 (CAT#: V2LY-0526-LY9838)

Rabbit Anti-LGMN Recombinant Antibody (D6S4H) (CAT#: CBMAB-CP1379-LY)

Sus scrofa (Pig) Recombinant LGMN protein, His Tag (CAT#: V2LY-0526-LY9837)

Mouse Anti-LGMN Recombinant Antibody (M1) (CAT#: CBMAB-A4943-LY)

LGMN Matched Antibody Pair (689) (CAT#: APMAB-689LY)

Mouse Anti-LGMN Recombinant Antibody (CBYJL-1540) (CAT#: CBMAB-L1319-YJ)

Mouse Anti-LGMN Recombinant Antibody (CBYC-A995) (CAT#: CBMAB-A4557-YC)

Mouse Anti-LGMN Recombinant Antibody (M2) (CAT#: CBMAB-L1325-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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