LGMN

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq]

Full Name

LGMN

Function

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity).
May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

Biological Process

Activation of cysteine-type endopeptidase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Antigen processing and presentation of exogenous peptide antigen via MHC class IITAS:Reactome
Associative learningBy SimilarityISS:ARUK-UCL
Cellular response to amyloid-betaManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular response to calcium ionManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular response to hepatocyte growth factor stimulusManual Assertion Based On ExperimentIDA:ARUK-UCL
Dendritic spine organizationBy SimilarityISS:ARUK-UCL
MemoryBy SimilarityISS:ARUK-UCL
Negative regulation of ERBB signaling pathwayISS:UniProtKB
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of multicellular organism growthIEA:Ensembl
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIGI:MGI
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of endothelial cell chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of long-term synaptic potentiationBy SimilarityISS:ARUK-UCL
Positive regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of monocyte chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
ProteolysisBy SimilarityISS:UniProtKB
Proteolysis involved in cellular protein catabolic processISS:UniProtKB
Receptor catabolic processISS:UniProtKB
Renal system processISS:UniProtKB
Response to acidic pHManual Assertion Based On ExperimentIDA:ARUK-UCL
Self proteolysisManual Assertion Based On ExperimentIDA:ARUK-UCL
Vacuolar protein processingManual Assertion Based On ExperimentIBA:GO_Central
Vitamin D metabolic processTAS:Reactome

Cellular Location

Lysosome

PTM

Glycosylated.
Activated by autocatalytic processing at pH 4.