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Rabbit Anti-LMAN1 Recombinant Antibody (CBYCL-364) (CBMAB-L0265-YC)

Provided herein is a Rabbit monoclonal antibody against Human LMAN1. The antibody can be used for immunoassay techniques, such as ELISA, WB, ICC.
See all LMAN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYCL-364
Antibody Isotype
IgG1
Application
ELISA, WB, ICC

Basic Information

Immunogen
A 19 amino acid peptide near the carboxy terminus of human ERGIC53
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Liquid in PBS, pH7.4, with 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
lectin, mannose-binding, 1
Introduction
LMAN1 (Lectin, Mannose Binding 1) is a protein coding gene. Diseases associated with LMAN1 include Factor V And Factor Viii, Combined Deficiency Of, 1 and Factor V And Factor Viii, Combined Deficiency Of, 2. Among its related pathways are Cytoskeletal Signaling and Protein processing in endoplasmic reticulum. And an important paralog is LMAN1L.
Entrez Gene ID
Human3998
Mouse70361
UniProt ID
HumanP49257
MouseQ9D0F3
Alternative Names
F5F8D; ERGIC-53; FMFD1; MR60; gp58; ERGIC53; MCFD1
Function
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Biological Process
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
Endoplasmic reticulum organizationManual Assertion Based On ExperimentIBA:GO_Central
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Positive regulation of organelle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentTAS:ProtInc
Protein transportIEA:UniProtKB-KW
Cellular Location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane
Involvement in disease
Factor V and factor VIII combined deficiency 1 (F5F8D1):
A blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
Topology
Lumenal: 31-477
Helical: 478-498
Cytoplasmic: 499-510
PTM
The N-terminal may be partly blocked.

Miller, M. H., Swaby, L. G., Vailoces, V. S., LaFratta, M., Zhang, Y., Zhu, X., ... & Tigno-Aranjuez, J. T. (2023). LMAN1 is a receptor for house dust mite allergens. Cell reports, 42(3).

Zhang, Y., Liu, Z., & Zhang, B. (2023). Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII. Blood Advances, 7(7), 1286-1296.

Tang, V. T., Abbineni, P. S., da Veiga Leprevost, F., Basrur, V., Emmer, B. T., Nesvizhskii, A., & Ginsburg, D. (2023). Identification of LMAN1 and SURF4 dependent secretory cargoes. bioRxiv, 2023-04.

Zhang, Y., Zhu, M., Zheng, C., Wei, W., Emmer, B. T., & Zhang, B. (2022). LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin. Biochemical Journal, 479(7), 839-855.

Du, Q., Lin, Y., Zhang, W., He, F., Xu, Y., & Chen, Z. (2022). Bioinformatics analysis of LMAN1 expression, clinical characteristics, and its effects on cell proliferation and invasion in glioma. Brain Research, 1789, 147952.

Alsheikh, S., Alghamdi, R., Alqatari, A., Alfareed, A., & AlSaleh, M. (2022). Combined factor V and VIII deficiency with LMAN1 mutation: a report of 3 Saudi siblings. The American Journal of Case Reports, 23, e937312-1.

Zhang, Y., Liu, Z., & Zhang, B. (2022). Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII. bioRxiv, 2022-09.

Everett, L. A., Khoriaty, R. N., Zhang, B., & Ginsburg, D. (2020). Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression. Blood Advances, 4(22), 5635-5643.

Fu, Y. L., Zhang, B., & Mu, T. W. (2019). LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors. Biochemical and biophysical research communications, 511(2), 356-362.

Zhu, M., Zheng, C., Wei, W., Everett, L., Ginsburg, D., & Zhang, B. (2018). Analysis of MCFD2-and LMAN1-deficient mice demonstrates distinct functions in vivo. Blood Advances, 2(9), 1014-1021.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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