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Mouse Anti-LMAN1 Recombinant Antibody (CBFYE-1492) (CBMAB-E2125-FY)

This product is mouse antibody that recognizes LMAN1. The antibody CBFYE-1492 can be used for immunoassay techniques such as: FC, IF, IHC, WB.
See all LMAN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Monkey, Dog
Clone
CBFYE-1492
Antibody Isotype
IgG1
Application
FC, IF, IHC, WB

Basic Information

Immunogen
Full length recombinant human ERGIC-53
Specificity
Human, Rat, Monkey, Dog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1%BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lectin, mannose-binding, 1
Introduction
The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport.
Entrez Gene ID
Human3998
Dog476186
Rat116666
Monkey697449
UniProt ID
HumanP49257
DogE2QW60
RatQ62902
MonkeyQ9TU32
Alternative Names
MR60; gp58; F5F8D; FMFD1; MCFD1; ERGIC53; ERGIC-53
Function
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Biological Process
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
Endoplasmic reticulum organizationManual Assertion Based On ExperimentIBA:GO_Central
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Positive regulation of organelle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentTAS:ProtInc
Protein transportIEA:UniProtKB-KW
Cellular Location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane
Involvement in disease
Factor V and factor VIII combined deficiency 1 (F5F8D1):
A blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
Topology
Lumenal: 31-477
Helical: 478-498
Cytoplasmic: 499-510
PTM
The N-terminal may be partly blocked.

Miller, M. H., Swaby, L. G., Vailoces, V. S., LaFratta, M., Zhang, Y., Zhu, X., ... & Tigno-Aranjuez, J. T. (2023). LMAN1 is a receptor for house dust mite allergens. Cell reports, 42(3).

Zhang, Y., Liu, Z., & Zhang, B. (2023). Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII. Blood Advances, 7(7), 1286-1296.

Tang, V. T., Abbineni, P. S., da Veiga Leprevost, F., Basrur, V., Emmer, B. T., Nesvizhskii, A., & Ginsburg, D. (2023). Identification of LMAN1 and SURF4 dependent secretory cargoes. bioRxiv, 2023-04.

Zhang, Y., Zhu, M., Zheng, C., Wei, W., Emmer, B. T., & Zhang, B. (2022). LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin. Biochemical Journal, 479(7), 839-855.

Du, Q., Lin, Y., Zhang, W., He, F., Xu, Y., & Chen, Z. (2022). Bioinformatics analysis of LMAN1 expression, clinical characteristics, and its effects on cell proliferation and invasion in glioma. Brain Research, 1789, 147952.

Alsheikh, S., Alghamdi, R., Alqatari, A., Alfareed, A., & AlSaleh, M. (2022). Combined factor V and VIII deficiency with LMAN1 mutation: a report of 3 Saudi siblings. The American Journal of Case Reports, 23, e937312-1.

Zhang, Y., Liu, Z., & Zhang, B. (2022). Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII. bioRxiv, 2022-09.

Everett, L. A., Khoriaty, R. N., Zhang, B., & Ginsburg, D. (2020). Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression. Blood Advances, 4(22), 5635-5643.

Fu, Y. L., Zhang, B., & Mu, T. W. (2019). LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors. Biochemical and biophysical research communications, 511(2), 356-362.

Zhu, M., Zheng, C., Wei, W., Everett, L., Ginsburg, D., & Zhang, B. (2018). Analysis of MCFD2-and LMAN1-deficient mice demonstrates distinct functions in vivo. Blood Advances, 2(9), 1014-1021.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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