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Rabbit Anti-LMAN1 Recombinant Antibody (E2B6H) (CBMAB-CP1399-LY)

The product is antibody recognizes LMAN1. The antibody E2B6H immunoassay techniques such as: WB.
See all LMAN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
E2B6H
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu366 of human LMAN1 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lectin, mannose-binding, 1
Entrez Gene ID
Human3998
Mouse70361
Rat116666
UniProt ID
HumanP49257
MouseQ9D0F3
RatQ62902
Function
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Biological Process
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
Endoplasmic reticulum organizationManual Assertion Based On ExperimentIBA:GO_Central
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Positive regulation of organelle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentTAS:ProtInc
Protein transportIEA:UniProtKB-KW
Cellular Location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane
Involvement in disease
Factor V and factor VIII combined deficiency 1 (F5F8D1):
A blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
Topology
Lumenal: 31-477
Helical: 478-498
Cytoplasmic: 499-510
PTM
The N-terminal may be partly blocked.

Miller, M. H., Swaby, L. G., Vailoces, V. S., LaFratta, M., Zhang, Y., Zhu, X., ... & Tigno-Aranjuez, J. T. (2023). LMAN1 is a receptor for house dust mite allergens. Cell reports, 42(3).

Zhang, Y., Liu, Z., & Zhang, B. (2023). Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII. Blood Advances, 7(7), 1286-1296.

Tang, V. T., Abbineni, P. S., da Veiga Leprevost, F., Basrur, V., Emmer, B. T., Nesvizhskii, A., & Ginsburg, D. (2023). Identification of LMAN1 and SURF4 dependent secretory cargoes. bioRxiv, 2023-04.

Zhang, Y., Zhu, M., Zheng, C., Wei, W., Emmer, B. T., & Zhang, B. (2022). LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin. Biochemical Journal, 479(7), 839-855.

Du, Q., Lin, Y., Zhang, W., He, F., Xu, Y., & Chen, Z. (2022). Bioinformatics analysis of LMAN1 expression, clinical characteristics, and its effects on cell proliferation and invasion in glioma. Brain Research, 1789, 147952.

Alsheikh, S., Alghamdi, R., Alqatari, A., Alfareed, A., & AlSaleh, M. (2022). Combined factor V and VIII deficiency with LMAN1 mutation: a report of 3 Saudi siblings. The American Journal of Case Reports, 23, e937312-1.

Zhang, Y., Liu, Z., & Zhang, B. (2022). Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII. bioRxiv, 2022-09.

Everett, L. A., Khoriaty, R. N., Zhang, B., & Ginsburg, D. (2020). Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression. Blood Advances, 4(22), 5635-5643.

Fu, Y. L., Zhang, B., & Mu, T. W. (2019). LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors. Biochemical and biophysical research communications, 511(2), 356-362.

Zhu, M., Zheng, C., Wei, W., Everett, L., Ginsburg, D., & Zhang, B. (2018). Analysis of MCFD2-and LMAN1-deficient mice demonstrates distinct functions in vivo. Blood Advances, 2(9), 1014-1021.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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