Mouse Anti-LMAN2 Recombinant Antibody (CBYCL-365) (CBMAB-L0266-YC)

Name: Mouse Anti-LMAN2 Recombinant Antibody (CBYCL-365)
SKU: CBMAB-L0266-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-365

Application

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4, with 0.05% sodium azide, 1% BSA

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LECTIN, MANNOSE BINDING 2

Introduction

LMAN2 is a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control.

Entrez Gene ID

10960

UniProt ID

Q12907

Alternative Names

Lectin; Lectin precursor

Function

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).

Biological Process

Endoplasmic reticulum organizationManual Assertion Based On ExperimentIBA:GO_Central
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Protein transportIEA:UniProtKB-KW
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane

Topology

Lumenal: 45-322
Helical: 323-345
Cytoplasmic: 346-356

Das, D., Lamothe, S. M., Baronas, V. A., & Kurata, H. T. (2023). Competition between Slc7a5 and LMAN2 for modulation of Kv1. 2 gating. Biophysical Journal, 122(3), 518a.

Lamothe, S. M., Das, D., Wong, A., Hao, Y., Baronas, V. A., & Kurata, H. T. (2023). Modulation of Kv1. 2 redox-sensitive gating by the transmembrane lectin LMAN2. Biophysical Journal, 122(3), 243a.

Yamamoto, K. (2023). Expression and binding assay of vesicular integral membrane protein 36 (VIP36, LMAN2).

Bao, J., Zha, Y., Chen, S., Yuan, J., Qiao, J., Cao, L., ... & Shao, M. (2022). The importance of serum LMAN2 level in septic shock and prognosis prediction in sepsis patients. Heliyon, 8(11).

Zhang, D., Ye, L., Hu, S., Zhu, Q., Li, C., & Zhu, C. (2022). Comprehensive analysis of the expression and prognostic value of LMAN2 in HER2+ breast cancer. Journal of Immunology Research, 2022.

Bettencourt, C., Foti, S. C., Miki, Y., Botia, J., Chatterjee, A., Warner, T. T., ... & Holton, J. L. (2020). White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy. Acta neuropathologica, 139, 135-156.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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