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Mouse Anti-LMAN2 Recombinant Antibody (CBYJL-1808) (CBMAB-L1749-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lectin Mannose Binding 2 (LMAN2). The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all LMAN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1808
Antibody Isotype
IgG2a
Application
ELISA, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 45-322

Target

Full Name
LECTIN, MANNOSE BINDING 2
Introduction
LMAN2 is a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. LMAN2 binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and heat shock protein binding. An important paralog of this gene is LMAN2L.LMAN2 plays a role as an intracellular lectin in the early secretory pathway. LMAN2 interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. LMAN2 is involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).
Entrez Gene ID
10960
UniProt ID
Q12907
Alternative Names
Lectin; Mannose Binding 2 2 3 5Vesicular Integral-Membrane Protein 36 3 4Glycoprotein GP36b 3 4C5orf8 3 4VIP36 3 4Vesicular Integral-Membrane Protein VIP36 3
Function
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).
Biological Process
Endoplasmic reticulum organizationManual Assertion Based On ExperimentIBA:GO_Central
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Protein transportIEA:UniProtKB-KW
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane
Topology
Lumenal: 45-322
Helical: 323-345
Cytoplasmic: 346-356
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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