Human Recombinant LMAN2 protein, His Tag (V2LY-0526-LY5325)

Name: Human Recombinant LMAN2 protein, His Tag
SKU: V2LY-0526-LY5325
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant LMAN2 protein, His Tag consist of Amino Acid: 45-322 and predicts a molecular mass of 33.2 kDa.

Molecule Mass

33.2 kDa

Verified

HPLC

Sequence

Amino Acid: 45-322

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

LECTIN, MANNOSE BINDING 2

Function

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).

Biological Process

Endoplasmic reticulum organizationManual Assertion Based On ExperimentIBA:GO_Central
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Protein transportIEA:UniProtKB-KW
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane

Topology

Lumenal: 45-322
Helical: 323-345
Cytoplasmic: 346-356

Das, D., Lamothe, S. M., Baronas, V. A., & Kurata, H. T. (2023). Competition between Slc7a5 and LMAN2 for modulation of Kv1. 2 gating. Biophysical Journal, 122(3), 518a.

Lamothe, S. M., Das, D., Wong, A., Hao, Y., Baronas, V. A., & Kurata, H. T. (2023). Modulation of Kv1. 2 redox-sensitive gating by the transmembrane lectin LMAN2. Biophysical Journal, 122(3), 243a.

Yamamoto, K. (2023). Expression and binding assay of vesicular integral membrane protein 36 (VIP36, LMAN2).

Bao, J., Zha, Y., Chen, S., Yuan, J., Qiao, J., Cao, L., ... & Shao, M. (2022). The importance of serum LMAN2 level in septic shock and prognosis prediction in sepsis patients. Heliyon, 8(11).

Zhang, D., Ye, L., Hu, S., Zhu, Q., Li, C., & Zhu, C. (2022). Comprehensive analysis of the expression and prognostic value of LMAN2 in HER2+ breast cancer. Journal of Immunology Research, 2022.

Bettencourt, C., Foti, S. C., Miki, Y., Botia, J., Chatterjee, A., Warner, T. T., ... & Holton, J. L. (2020). White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy. Acta neuropathologica, 139, 135-156.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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