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Mouse Anti-MAPK8IP2 (AA 226-421) Recombinant Antibody (CBFYM-0407) (CBMAB-M0515-FY)

This product is mouse antibody that recognizes MAPK8IP2. The antibody CBFYM-0407 can be used for immunoassay techniques such as: ICC, IHC, WB.
See all MAPK8IP2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBFYM-0407
Antibody Isotype
IgG1
Application
ICC, IHC, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.1% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 226-421

Target

Full Name
mitogen-activated protein kinase 8 interacting protein 2
Introduction
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases.
Entrez Gene ID
60597
UniProt ID
Q9ERE9
Alternative Names
Mitogen-Activated Protein Kinase 8 Interacting Protein 2; JNK-Interacting Protein 2; JNK MAP Kinase Scaffold Protein 2; Islet-Brain 2; PRKM8IPL; IB-2; JIP2; IB2
Function
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Biological Process
Behavioral fear responseISS:BHF-UCL
Dendrite morphogenesisISS:BHF-UCL
Excitatory postsynaptic potentialISS:BHF-UCL
JNK cascadeIEA:Ensembl
MAPK cascadeIDA:MGI
Mating behaviorIEA:Ensembl
Negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Nonassociative learningISS:BHF-UCL
Positive regulation of stress-activated MAPK cascadeIEA:Ensembl
Regulation of AMPA receptor activityISS:BHF-UCL
Regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of NMDA receptor activityISS:BHF-UCL
Regulation of signaling receptor activityISS:BHF-UCL
Regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Signal complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Social behaviorISS:BHF-UCL
Cellular Location
Cytoplasm
Accumulates in cell surface projections.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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