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MAPK8IP2

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases.

Full Name

mitogen-activated protein kinase 8 interacting protein 2

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Biological Process

Behavioral fear responseISS:BHF-UCL
Dendrite morphogenesisISS:BHF-UCL
Excitatory postsynaptic potentialISS:BHF-UCL
JNK cascadeIEA:Ensembl
MAPK cascadeIDA:MGI
Mating behaviorIEA:Ensembl
Negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Nonassociative learningISS:BHF-UCL
Positive regulation of stress-activated MAPK cascadeIEA:Ensembl
Regulation of AMPA receptor activityISS:BHF-UCL
Regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of NMDA receptor activityISS:BHF-UCL
Regulation of signaling receptor activityISS:BHF-UCL
Regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Signal complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Social behaviorISS:BHF-UCL

Cellular Location

Cytoplasm
Accumulates in cell surface projections.

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Anti-MAPK8IP2 antibodies

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Mouse Anti-MAPK8IP2 Recombinant Antibody (A1013) (CBMAB-AP10960LY)

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Target: MAPK8IP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: A1013

Application*: ICC/IF, IHC, WB

Mouse Anti-MAPK8IP2 (AA 226-421) Recombinant Antibody (CBFYM-0407) (CBMAB-M0515-FY)

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Target: MAPK8IP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYM-0407

Application*: IC, IH, WB

Mouse Anti-MAPK8IP2 Recombinant Antibody (S135-37) (CBMAB-0448-WJ)

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Target: MAPK8IP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat

Clone: S135-37

Application*: WB, IH, IF, IC

Mouse Anti-MAPK8IP2 Recombinant Antibody (C-10) (CBMAB-0297-WJ)

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Target: MAPK8IP2

Host: Mouse

Specificity: Human

Clone: C-10

Application*: WB, IP, IF, E

Rabbit Anti-MAPK8IP2 Recombinant Antibody (EG1715) (CBMAB-EN2053-LY)

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Target: MAPK8IP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1715

Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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