MAPK8IP2

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases.
Full Name
mitogen-activated protein kinase 8 interacting protein 2
Function
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Biological Process
Behavioral fear responseISS:BHF-UCL
Dendrite morphogenesisISS:BHF-UCL
Excitatory postsynaptic potentialISS:BHF-UCL
JNK cascadeIEA:Ensembl
MAPK cascadeIDA:MGI
Mating behaviorIEA:Ensembl
Negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Nonassociative learningISS:BHF-UCL
Positive regulation of stress-activated MAPK cascadeIEA:Ensembl
Regulation of AMPA receptor activityISS:BHF-UCL
Regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of NMDA receptor activityISS:BHF-UCL
Regulation of signaling receptor activityISS:BHF-UCL
Regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Signal complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Social behaviorISS:BHF-UCL
Cellular Location
Cytoplasm
Accumulates in cell surface projections.
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Anti-MAPK8IP2 antibodies

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Mouse Anti-MAPK8IP2 Recombinant Antibody (A1013) (CBMAB-AP10960LY)

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Target: MAPK8IP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A1013
Application*: ICC/IF, IHC, WB
Datasheet SDS

Mouse Anti-MAPK8IP2 (AA 226-421) Recombinant Antibody (CBFYM-0407) (CBMAB-M0515-FY)

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Target: MAPK8IP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-0407
Application*: IC, IH, WB
Datasheet SDS

Mouse Anti-MAPK8IP2 Recombinant Antibody (S135-37) (CBMAB-0448-WJ)

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Target: MAPK8IP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: S135-37
Application*: WB, IH, IF, IC
Datasheet SDS

Mouse Anti-MAPK8IP2 Recombinant Antibody (C-10) (CBMAB-0297-WJ)

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Target: MAPK8IP2
Host: Mouse
Specificity: Human
Clone: C-10
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-MAPK8IP2 Recombinant Antibody (EG1715) (CBMAB-EN2053-LY)

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Target: MAPK8IP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1715
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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