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Mouse Anti-MAPK8IP2 Recombinant Antibody (S135-37) (CBMAB-0448-WJ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
S135-37
Application
WB, IHC, IF, ICC
Immunogen
Fusion protein amino acids 226-421 of mouse JIP-2/IB-2.
Specificity
Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
mitogen-activated protein kinase 8 interacting protein 2
Introduction
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. Diseases associated with MAPK8IP2 include Cervical Verrucous Carcinoma and Ameloblastic Carcinoma. Among its related pathways are ERK Signaling and Akt Signaling. An important paralog of this gene is MAPK8IP1.
Entrez Gene ID
Mouse60597
Rat315220
UniProt ID
MouseQ9ERE9
RatG3V9M2
Alternative Names
MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2; PRKM8 interacting protein like, PRKM8IPL; C-Jun-amino-terminal kinase-interacting protein 2; IB2; islet brain 2; JIP2; JNK interacting protein 2; IB-2; JIP-2; islet-brain 2; islet-brain-2; JNK-interacting protein 2; homologous to mouse JIP-1; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; mitogen-activated protein kinase 8-interacting protein 2; PRKM8IPL
Function
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Biological Process
Behavioral fear responseISS:BHF-UCL
Dendrite morphogenesisISS:BHF-UCL
Excitatory postsynaptic potentialISS:BHF-UCL
JNK cascadeIEA:Ensembl
MAPK cascadeIDA:MGI
Mating behaviorIEA:Ensembl
Negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Nonassociative learningISS:BHF-UCL
Positive regulation of stress-activated MAPK cascadeIEA:Ensembl
Regulation of AMPA receptor activityISS:BHF-UCL
Regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of NMDA receptor activityISS:BHF-UCL
Regulation of signaling receptor activityISS:BHF-UCL
Regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Signal complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Social behaviorISS:BHF-UCL
Cellular Location
Cytoplasm
Accumulates in cell surface projections.

Huang, J., Liu, W., Lin, B. Y., Li, J. C., Lu, J., & Li, B. Y. (2023). Scaffold protein MAPK8IP2 expression is a robust prognostic factor in prostate cancer associated with AR signaling activity. Asian journal of andrology, 25(2), 198.

Zhenhao, Z., Ru, C., Xiaofeng, C., Heng, Y., & Gongxian, W. (2023). A novel circular RNA, circMAML3, promotes tumor progression of prostate cancer by regulating miR-665/MAPK8IP2 axis. Cell Death Discovery, 9(1), 455.

Zeng, Z., He, W., Jiang, Y., Jiang, H., Cheng, X., Deng, W., ... & Wang, G. (2022). MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer. BMC cancer, 22(1), 1162.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-MAPK8IP2 (AA 226-421) Recombinant Antibody (CBFYM-0407) (CAT#: CBMAB-M0515-FY)

Rabbit Anti-MAPK8IP2 Recombinant Antibody (EG1715) (CAT#: CBMAB-EN2053-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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