Rat Anti-MAPRE3 Recombinant Antibody (CBFYM-1677) (CBMAB-M1844-FY)

Name: Rat Anti-MAPRE3 Recombinant Antibody (CBFYM-1677)
SKU: CBMAB-M1844-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYM-1677

Application

Immunogen

Human EB3 fused to GST

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Microtubule Associated Protein RP/EB Family Member 3

Introduction

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.

Entrez Gene ID

22924

UniProt ID

Q9UPY8

Alternative Names

Microtubule Associated Protein RP/EB Family Member 3; EB1 Protein Family Member 3; End-Binding Protein 3; EBF3; RP3; EB3; Microtubule-Associated Protein RP/EB Family Member 3; APC Binding Protein; EBF3-S

Function

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570).
Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570).
May play a role in cell migration (By similarity).

Biological Process

Cell divisionIEA:UniProtKB-KW
Positive regulation of cyclin-dependent protein serine/threonine kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of microtubule plus-end bindingIEA:Ensembl
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription, DNA-templatedBy SimilarityISS:BHF-UCL
Protein localizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Protein localization to microtubule plus-endManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Spindle assemblyManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytoskeleton
Associated with the microtubule network. Detected at the plus end of microtubules.

Zhang, Y., Liu, F., Zheng, J., Jiang, K., Ai, H., Liu, L., & Mao, D. (2024). MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo. Experimental Cell Research, 113913.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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