MAPRE3

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]
Full Name
Microtubule Associated Protein RP/EB Family Member 3
Function
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570).
Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570).
May play a role in cell migration (By similarity).
Biological Process
Cell divisionIEA:UniProtKB-KW
Positive regulation of cyclin-dependent protein serine/threonine kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of microtubule plus-end bindingIEA:Ensembl
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription, DNA-templatedBy SimilarityISS:BHF-UCL
Protein localizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Protein localization to microtubule plus-endManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Spindle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Associated with the microtubule network. Detected at the plus end of microtubules.
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Anti-MAPRE3 antibodies

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Rat Anti-MAPRE3 Recombinant Antibody (KT53) (CBMAB-AO375LY)

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Target: MAPRE3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: KT53
Application*: WB
Datasheet SDS

Mouse Anti-MAPRE3 Recombinant Antibody (3D7) (CBMAB-A5292-LY)

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Target: MAPRE3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D7
Application*: WB, E
Datasheet SDS

Rat Anti-MAPRE3 Recombinant Antibody (CBFYM-1681) (CBMAB-M1848-FY)

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Target: MAPRE3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1681
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-MAPRE3 (AA 125-219) Recombinant Antibody (CBFYM-1680) (CBMAB-M1847-FY)

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Target: MAPRE3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1680
Application*: E, WB
Datasheet SDS

Mouse Anti-MAPRE3 (AA 125-218) Recombinant Antibody (CBFYM-1679) (CBMAB-M1846-FY)

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Target: MAPRE3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1679
Application*: IF, SE, E, WB-Re
Datasheet SDS

Mouse Anti-MAPRE3 (AA 125-218) Recombinant Antibody (CBFYM-1678) (CBMAB-M1845-FY)

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Target: MAPRE3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1678
Application*: E, IF, WB
Datasheet SDS

Rat Anti-MAPRE3 Recombinant Antibody (CBFYM-1677) (CBMAB-M1844-FY)

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Target: MAPRE3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1677
Application*: IF
Datasheet SDS

Mouse Anti-MAPRE3 Recombinant Antibody (CBFYM-1676) (CBMAB-M1843-FY)

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Target: MAPRE3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1676
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-MAPRE3 Recombinant Antibody (CBFYM-0568) (CBMAB-M0697-FY)

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Target: MAPRE3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0568
Application*: E, WB
Datasheet SDS

Rat Anti-MAPRE3 Recombinant Antibody (CBFYE-1548) (CBMAB-E2192-FY)

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Target: MAPRE3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1548
Application*: E, WB, IP
Datasheet SDS

Rat Anti-MAPRE3 Recombinant Antibody (KT36) (CBMAB-E2191-FY)

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Target: MAPRE3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: KT36
Application*: E, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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