MAPRE3

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

Microtubule Associated Protein RP/EB Family Member 3

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570).
Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570).
May play a role in cell migration (By similarity).

Cell divisionIEA:UniProtKB-KW
Positive regulation of cyclin-dependent protein serine/threonine kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of microtubule plus-end bindingIEA:Ensembl
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription, DNA-templatedBy SimilarityISS:BHF-UCL
Protein localizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Protein localization to microtubule plus-endManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Spindle assemblyManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm, cytoskeleton
Associated with the microtubule network. Detected at the plus end of microtubules.