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Rat Anti-MAPRE3 Recombinant Antibody (CBFYE-1548) (CBMAB-E2192-FY)

This product is rat antibody that recognizes MAPRE3. The antibody CBFYE-1548 can be used for immunoassay techniques such as: ELISA, WB, IP.
See all MAPRE3 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBFYE-1548
Antibody Isotype
IgG2a
Application
ELISA, WB, IP

Basic Information

Immunogen
Purified full-length human EB3-GST fusion protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Microtubule Associated Protein RP/EB Family Member 3
Introduction
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.
Entrez Gene ID
22924
UniProt ID
Q9UPY8
Alternative Names
Microtubule Associated Protein RP/EB Family Member 3; EB1 Protein Family Member 3; End-Binding Protein 3; EBF3; RP3; EB3; Microtubule-Associated Protein RP/EB Family Member 3; APC Binding Protein; EBF3-S
Function
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570).
Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570).
May play a role in cell migration (By similarity).
Biological Process
Cell divisionIEA:UniProtKB-KW
Positive regulation of cyclin-dependent protein serine/threonine kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of microtubule plus-end bindingIEA:Ensembl
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription, DNA-templatedBy SimilarityISS:BHF-UCL
Protein localizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Protein localization to microtubule plus-endManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Spindle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Associated with the microtubule network. Detected at the plus end of microtubules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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