Mouse Anti-METTL21A Antibody (2D2) (CBMAB-0673-YC)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
2D2
Application
IP, MA
Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
METTL21A
Introduction
METTL21A (methyltransferase like 21A) is a protein that has methyltransferase activity and Hsp70 protein binding. Among its related pathways are protein methylation and metabolism of proteins. An important paralog of this gene is EEF1AKMT3.
Entrez Gene ID
151194
UniProt ID
Q8WXB1
Alternative Names
FAM119A; HCA557b; HSPA-KMT; LOC151194
Function
S-adenosyl-L-methionine-dependent methyltransferase that mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557).

N3-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557).
Biological Process
tRNA methylation Source: UniProtKB
Cellular Location
Cytoplasm

Li, J., Feng, S., Ma, X., Yuan, S., & Wang, X. (2022). METTL21A, a non-histone methyltransferase, is dispensable for spermatogenesis and male fertility in mice. International Journal of Molecular Sciences, 23(4), 1942.

Yang, X., Zoabi, M., Hausmann, S., Flores, N. M., Lu, X., Wu, J., ... & Mazur, P. K. (2022). Abstract A080: METTL21A inhibits pancreatic ductal adenocarcinoma tumorigenesis through methylation of HSPA1/8. Cancer Research, 82(22_Supplement), A080-A080.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-METTL21A Recombinant Antibody (CBFYM-2125) (CAT#: CBMAB-M2307-FY)

Mouse Anti-METTL21A Recombinant Antibody (CBXF-2525) (CAT#: CBMAB-F1143-CQ)

Mouse Anti-METTL21A Recombinant Antibody (2G7) (CAT#: CBMAB-F0091-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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